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Find low faresSouthwest® flights from Cleveland to St. Louis from $120
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Low fares from Cleveland to St. Louis
$
Cleveland (CLE)to
St. Louis (STL)
Depart: 04/11/2026
One-way
Basic
From
$120
Seen: 16 hrs ago
Cleveland (CLE)to
St. Louis (STL)
Depart: 04/25/2026
One-way
Basic
From
$120
Seen: 11 hrs ago
Cleveland (CLE)to
St. Louis (STL)
Depart: 04/07/2026
One-way
Basic
From
$120
Seen: 15 hrs ago
Cleveland (CLE)to
St. Louis (STL)
Depart: 04/18/2026
One-way
Basic
From
$120
Seen: 15 hrs ago
Cleveland (CLE)to
St. Louis (STL)
Depart: 04/14/2026
One-way
Basic
From
$120
Seen: 15 hrs ago
Cleveland (CLE)to
St. Louis (STL)
Depart: 04/15/2026
One-way
Basic
From
$120
Seen: 15 hrs ago
Explore flights from Cleveland to St. Louis
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Flight Details
Departing from:
Hopkins International Airport
Arriving at:
Lambert-St Louis Int'l Airport
Average flight time:
1 hour 35 minutes
Distance:
487 miles
Route Information
146† Weekly flights
- 2‡ Nonstop flights per day Monday through Friday
- 1‡ Nonstop flight on Saturday
- 2‡ Nonstop flights on Sunday
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
The average flight time from Cleveland to St. Louis is 1 hour 35 minutes.
There are 146 weekly flights from Cleveland to St. Louis on Southwest Airlines.
Yes, Southwest flies nonstop from Cleveland to St. Louis 2 times per day from Monday through Friday.
Yes, Southwest flies nonstop from Cleveland to St. Louis once per day on Saturdays and 2 times per day on Sundays.
To find the lowest fares by day and time to fly Cleveland to St. Louis with Southwest, check out our Low Fare Calendar.
You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
Yes! Flights from Cleveland to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.