Southwest® flights from Columbus to St. Louis from $99

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Low fares from Columbus to St. Louis

$

Columbus (CMH)to

St. Louis (STL)
Depart: 05/05/2026

One-way

Basic

From
$99
Seen: 19 hrs ago

Columbus (CMH)to

St. Louis (STL)
Depart: 04/01/2026

One-way

Basic

From
$99
Seen: 22 hrs ago

Columbus (CMH)to

St. Louis (STL)
Depart: 04/21/2026

One-way

Basic

From
$99
Seen: 23 hrs ago

Columbus (CMH)to

St. Louis (STL)
Depart: 03/16/2026

One-way

Basic

From
$108
Seen: 23 hrs ago

Columbus (CMH)to

St. Louis (STL)
Depart: 03/09/2026

One-way

Basic

From
$108
Seen: 19 hrs ago

Columbus (CMH)to

St. Louis (STL)
Depart: 03/30/2026

One-way

Basic

From
$108
Seen: 15 hrs ago

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Explore flights from Columbus to St. Louis

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Port Columbus International Airport
Arriving at:
Lambert-St Louis Int'l Airport
Average flight time:
1 hour 28 minutes
Distance:
409 miles

Route Information

152† Weekly flights
  • 1‡ Nonstop flight per day Monday through Friday
  • 1‡ Nonstop flight on Saturday
  • 2‡ Nonstop flights on Sunday

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

The average flight time from Columbus to St. Louis is 1 hour 28 minutes.
There are 152 weekly flights from Columbus to St. Louis on Southwest Airlines.
Yes, Southwest flies nonstop from Columbus to St. Louis once per day from Monday through Friday.
Yes, Southwest flies nonstop from Columbus to St. Louis once per day on Saturdays and 2 times per day on Sundays.
To find the lowest fares by day and time to fly Columbus to St. Louis with Southwest, check out our Low Fare Calendar.
You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
Yes! Flights from Columbus to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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