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Find low faresSouthwest® flights from Harlingen/South Padre Island to San Diego from $149
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1 Passenger
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Low fares from Harlingen/South Padre Island to San Diego
$
Harlingen/South Padre Island (HRL)to
San Diego (SAN)
Depart: 04/27/2026
One-way
Basic
From
$149
Seen: 10 hrs ago
Harlingen/South Padre Island (HRL)to
San Diego (SAN)
Depart: 03/03/2026
One-way
Basic
From
$154
Seen: 5 hrs ago
Harlingen/South Padre Island (HRL)to
San Diego (SAN)
Depart: 03/10/2026
One-way
Basic
From
$159
Seen: 8 hrs ago
Harlingen/South Padre Island (HRL)to
San Diego (SAN)
Depart: 02/20/2026
One-way
Basic
From
$170
Seen: 7 hrs ago
Harlingen/South Padre Island (HRL)to
San Diego (SAN)
Depart: 02/22/2026
One-way
Basic
From
$170
Seen: 9 hrs ago
Harlingen/South Padre Island (HRL)to
San Diego (SAN)
Depart: 03/23/2026
One-way
Basic
From
$175
Seen: 18 hrs ago
Explore flights from Harlingen/South Padre Island to San Diego
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Flight Details
Departing from:
Valley International Airport
Arriving at:
San Diego International Airport
Distance:
1257 miles
Route Information
85† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 85 weekly flights from Harlingen/South Padre Island to San Diego on Southwest Airlines.
To find the lowest fares by day and time to fly Harlingen/South Padre Island to San Diego with Southwest, check out our Low Fare Calendar.
You can rent a car at San Diego International Airport book yours with your flight.
Yes! Flights from Harlingen/South Padre Island to San Diego—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.