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Find low faresSouthwest® flights from Midland/Odessa to St. Louis from $159
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Low fares from Midland/Odessa to St. Louis
$
Midland/Odessa (MAF)to
St. Louis (STL)
Depart: 03/04/2026
One-way
Basic
From
$159
Seen: 2 hrs ago
Midland/Odessa (MAF)to
St. Louis (STL)
Depart: 04/01/2026
One-way
Basic
From
$171
Seen: 4 hrs ago
Midland/Odessa (MAF)to
St. Louis (STL)
Depart: 03/04/2026
One-way
Choice
From
$194
Seen: 2 hrs ago
Midland/Odessa (MAF)to
St. Louis (STL)
Depart: 03/12/2026
One-way
Basic
From
$194
Seen: 55 minutes ago
Midland/Odessa (MAF)to
St. Louis (STL)
Depart: 03/06/2026
One-way
Basic
From
$194
Seen: 1 hour ago
Midland/Odessa (MAF)to
St. Louis (STL)
Depart: 03/19/2026
One-way
Basic
From
$204
Seen: 1 hour ago
Explore flights from Midland/Odessa to St. Louis
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Flight Details
Departing from:
Midland International Airport
Arriving at:
Lambert-St Louis Int'l Airport
Distance:
815 miles
Route Information
120† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 120 weekly flights from Midland/Odessa to St. Louis on Southwest Airlines.
To find the lowest fares by day and time to fly Midland/Odessa to St. Louis with Southwest, check out our Low Fare Calendar.
You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
Yes! Flights from Midland/Odessa to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.