Southwest® flights from New York (LaGuardia) to Des Moines from $183

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Low fares from New York (LaGuardia) to Des Moines

$

New York (LaGuardia) (LGA)to

Des Moines (DSM)
Depart: 06/27/2026

One-way

Basic

From
$183
Seen: 21 hrs ago

New York (LaGuardia) (LGA)to

Des Moines (DSM)
Depart: 04/29/2026

One-way

Basic

From
$209
Seen: 17 hrs ago

New York (LaGuardia) (LGA)to

Des Moines (DSM)
Depart: 04/28/2026

One-way

Basic

From
$209
Seen: 16 hrs ago

New York (LaGuardia) (LGA)to

Des Moines (DSM)
Depart: 04/27/2026

One-way

Basic

From
$219
Seen: 17 hrs ago

New York (LaGuardia) (LGA)to

Des Moines (DSM)
Depart: 06/22/2026

One-way

Basic

From
$219
Seen: 7 minutes ago

New York (LaGuardia) (LGA)to

Des Moines (DSM)
Depart: 04/23/2026

One-way

Basic

From
$219
Seen: 15 hrs ago

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Explore flights from New York (LaGuardia) to Des Moines

Apr 2026
From$209*
Seen: 17 hrs ago
One Way/Basic
May 2026
From$219*
Seen: 17 hrs ago
One Way/Basic
Jun 2026
From$183*
Seen: 21 hrs ago
One Way/Basic
$209
$276
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    • Range$209-$276

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    La Guardia Airport
    Arriving at:
    Des Moines Airport
    Distance:
    1031 miles

    Route Information

    52† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 52 weekly flights from New York (LaGuardia) to Des Moines on Southwest Airlines.
    To find the lowest fares by day and time to fly New York (LaGuardia) to Des Moines with Southwest, check out our Low Fare Calendar.
    You can rent a car at Des Moines Airport book yours with your flight.
    Yes! Flights from New York (LaGuardia) to Des Moines—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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