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Find low faresSouthwest® flights from Pensacola to St. Louis from $162
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1 Passenger
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Low fares from Pensacola to St. Louis
$
Pensacola (PNS)to
St. Louis (STL)
Depart: 02/24/2026
One-way
Basic
From
$162
Seen: 15 hrs ago
Pensacola (PNS)to
St. Louis (STL)
Depart: 02/25/2026
One-way
Basic
From
$162
Seen: 15 hrs ago
Pensacola (PNS)to
St. Louis (STL)
Depart: 04/11/2026
One-way
Basic
From
$164
Seen: 14 hrs ago
Pensacola (PNS)to
St. Louis (STL)
Depart: 03/26/2026
One-way
Basic
From
$164
Seen: 10 hrs ago
Pensacola (PNS)to
St. Louis (STL)
Depart: 03/05/2026
One-way
Basic
From
$164
Seen: 12 hrs ago
Pensacola (PNS)to
St. Louis (STL)
Depart: 05/07/2026
One-way
Basic
From
$174
Seen: 15 hrs ago
Explore flights from Pensacola to St. Louis
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Flight Details
Departing from:
Pensacola International Airport
Arriving at:
Lambert-St Louis Int'l Airport
Average flight time:
1 hour 45 minutes
Distance:
598 miles
Route Information
75† Weekly flights
- 1‡ Nonstop flight per day Monday through Friday
- 1‡ Nonstop flight on Saturday
- 1‡ Nonstop flight on Sunday
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
The average flight time from Pensacola to St. Louis is 1 hour 45 minutes.
There are 75 weekly flights from Pensacola to St. Louis on Southwest Airlines.
Yes, Southwest flies nonstop from Pensacola to St. Louis once per day from Monday through Friday.
Yes, Southwest flies nonstop from Pensacola to St. Louis once per day on Saturdays and Sundays.
To find the lowest fares by day and time to fly Pensacola to St. Louis with Southwest, check out our Low Fare Calendar.
You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
Yes! Flights from Pensacola to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.