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Find low faresSouthwest® flights from Pittsburgh to St. Louis from $107
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Low fares from Pittsburgh to St. Louis
$
Pittsburgh (PIT)to
St. Louis (STL)
Depart: 03/09/2026
One-way
Basic
From
$107
Seen: 17 hrs ago
Pittsburgh (PIT)to
St. Louis (STL)
Depart: 04/23/2026
One-way
Basic
From
$107
Seen: 6 hrs ago
Pittsburgh (PIT)to
St. Louis (STL)
Depart: 04/08/2026
One-way
Basic
From
$107
Seen: 1 hour ago
Pittsburgh (PIT)to
St. Louis (STL)
Depart: 04/07/2026
One-way
Basic
From
$107
Seen: 1 hour ago
Pittsburgh (PIT)to
St. Louis (STL)
Depart: 03/12/2026
One-way
Basic
From
$107
Seen: 23 hrs ago
Pittsburgh (PIT)to
St. Louis (STL)
Depart: 04/01/2026
One-way
Basic
From
$107
Seen: 6 hrs ago
Explore flights from Pittsburgh to St. Louis
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Flight Details
Departing from:
Pittsburgh International Airport
Arriving at:
Lambert-St Louis Int'l Airport
Average flight time:
1 hour 48 minutes
Distance:
554 miles
Route Information
156† Weekly flights
- 1‡ Nonstop flight per day Monday through Friday
- 1‡ Nonstop flight on Saturday
- 2‡ Nonstop flights on Sunday
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
The average flight time from Pittsburgh to St. Louis is 1 hour 48 minutes.
There are 156 weekly flights from Pittsburgh to St. Louis on Southwest Airlines.
Yes, Southwest flies nonstop from Pittsburgh to St. Louis once per day from Monday through Friday.
Yes, Southwest flies nonstop from Pittsburgh to St. Louis once per day on Saturdays and 2 times per day on Sundays.
To find the lowest fares by day and time to fly Pittsburgh to St. Louis with Southwest, check out our Low Fare Calendar.
You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
Yes! Flights from Pittsburgh to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.