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Find low faresSouthwest® flights from Rochester to St. Louis from $149
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1 Passenger
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Low fares from Rochester to St. Louis
$
Rochester (ROC)to
St. Louis (STL)
Depart: 03/31/2026
One-way
Basic
From
$149
Seen: 23 hrs ago
Rochester (ROC)to
St. Louis (STL)
Depart: 03/31/2026
One-way
Choice
From
$184
Seen: 23 hrs ago
Rochester (ROC)to
St. Louis (STL)
Depart: 04/26/2026
One-way
Basic
From
$194
Seen: 14 hrs ago
Rochester (ROC)to
St. Louis (STL)
Depart: 04/26/2026
One-way
Choice
From
$229
Seen: 14 hrs ago
Rochester (ROC)to
St. Louis (STL)
Depart: 03/31/2026
One-way
Choice Preferred
From
$254
Seen: 23 hrs ago
Rochester (ROC)to
St. Louis (STL)
Depart: 03/20/2026
One-way
Basic
From
$259
Seen: 1 hour ago
Explore flights from Rochester to St. Louis
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Flight Details
Departing from:
Greater Rochester International Airport
Arriving at:
Lambert-St Louis Int'l Airport
Distance:
729 miles
Route Information
72† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 72 weekly flights from Rochester to St. Louis on Southwest Airlines.
To find the lowest fares by day and time to fly Rochester to St. Louis with Southwest, check out our Low Fare Calendar.
You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
Yes! Flights from Rochester to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.