Southwest® flights from San Diego to St. Louis from $179

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Low fares from San Diego to St. Louis

$

San Diego (SAN)to

St. Louis (STL)
Depart: 11/10/2026

One-way

Basic

From
$179
Seen: 20 hrs ago

San Diego (SAN)to

St. Louis (STL)
Depart: 11/14/2026

One-way

Basic

From
$179
Seen: 13 hrs ago

San Diego (SAN)to

St. Louis (STL)
Depart: 09/29/2026

One-way

Basic

From
$179
Seen: 10 hrs ago

San Diego (SAN)to

St. Louis (STL)
Depart: 10/03/2026

One-way

Basic

From
$179
Seen: 14 hrs ago

San Diego (SAN)to

St. Louis (STL)
Depart: 11/05/2026

One-way

Basic

From
$179
Seen: 12 hrs ago

San Diego (SAN)to

St. Louis (STL)
Depart: 10/20/2026

One-way

Basic

From
$179
Seen: 16 hrs ago

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Explore flights from San Diego to St. Louis

Aug 2026
From$533*
Seen: 21 hrs ago
One Way/Basic
Sep 2026
From$179*
Seen: 10 hrs ago
One Way/Basic
Oct 2026
From$179*
Seen: 13 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $184
cmp-daily-histogram-bars-legend-max-price-aria-label $620
Displaying fares for August-2026
  • SAN–STL, 08/20/2026: From $615
    20

    Thu

    AUG

  • SAN–STL, 08/21/2026: From $615
    21

    Fri

  • SAN–STL, 08/22/2026: From $620
    22

    Sat

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    23

    Sun

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    24

    Mon

  • SAN–STL, 08/25/2026: From $620
    25

    Tue

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    26

    Wed

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    27

    Thu

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    28

    Fri

  • SAN–STL, 08/29/2026: From $538
    29

    Sat

  • SAN–STL, 08/30/2026: From $538
    30

    Sun

  • SAN–STL, 08/31/2026: From $533
    31

    Mon

  • SAN–STL, 09/01/2026: From $538
    01

    Tue

    SEP

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    02

    Wed

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    03

    Thu

  • SAN–STL, 09/04/2026: From $380
    04

    Fri

  • SAN–STL, 09/05/2026: From $380
    05

    Sat

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    06

    Sun

  • SAN–STL, 09/07/2026: From $428
    07

    Mon

  • SAN–STL, 09/08/2026: From $380
    08

    Tue

  • SAN–STL, 09/09/2026: From $380
    09

    Wed

  • SAN–STL, 09/10/2026: From $184
    10

    Thu

  • SAN–STL, 09/11/2026: From $194
    11

    Fri

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    12

    Sat

  • SAN–STL, 09/13/2026: From $274
    13

    Sun

  • SAN–STL, 09/14/2026: From $184
    14

    Mon

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    15

    Tue

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    16

    Wed

  • SAN–STL, 09/17/2026: From $189
    17

    Thu

  • SAN–STL, 09/18/2026: From $194
    18

    Fri

  • SAN–STL, 09/19/2026: From $184
    19

    Sat

    • Range$184-$620

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    San Diego International Airport
    Arriving at:
    Lambert-St Louis Int'l Airport
    Average flight time:
    3 hours 39 minutes
    Distance:
    1557 miles

    Route Information

    156† Weekly flights
    • 1‡ Nonstop flight per day Monday through Friday
    • 1‡ Nonstop flight on Saturday
    • 2‡ Nonstop flights on Sunday

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    The average flight time from San Diego to St. Louis is 3 hours 39 minutes.
    There are 156 weekly flights from San Diego to St. Louis on Southwest Airlines.
    Yes, Southwest flies nonstop from San Diego to St. Louis once per day from Monday through Friday.
    Yes, Southwest flies nonstop from San Diego to St. Louis once per day on Saturdays and 2 times per day on Sundays.
    To find the lowest fares by day and time to fly San Diego to St. Louis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
    Yes! Flights from San Diego to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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