Southwest® flights from San Diego to St. Louis from $179

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Low fares from San Diego to St. Louis

$

San Diego (SAN)to

St. Louis (STL)
Depart: 09/05/2026

One-way

Basic

From
$179
Seen: 18 hrs ago

San Diego (SAN)to

St. Louis (STL)
Depart: 09/29/2026

One-way

Basic

From
$179
Seen: 16 hrs ago

San Diego (SAN)to

St. Louis (STL)
Depart: 10/27/2026

One-way

Basic

From
$179
Seen: 16 hrs ago

San Diego (SAN)to

St. Louis (STL)
Depart: 09/01/2026

One-way

Basic

From
$179
Seen: 3 hrs ago

San Diego (SAN)to

St. Louis (STL)
Depart: 11/04/2026

One-way

Basic

From
$179
Seen: 13 hrs ago

San Diego (SAN)to

St. Louis (STL)
Depart: 10/01/2026

One-way

Basic

From
$179
Seen: 17 hrs ago

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Explore flights from San Diego to St. Louis

Jul 2026
From$620*
Seen: 23 hrs ago
One Way/Basic
Aug 2026
From$179*
Seen: 8 hrs ago
One Way/Basic
Sep 2026
From$179*
Seen: 16 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $179
cmp-daily-histogram-bars-legend-max-price-aria-label $620
Displaying fares for July-2026
  • SAN–STL, 07/31/2026: From $620
    31

    Fri

    JUL

  • SAN–STL, 08/01/2026: From $615
    01

    Sat

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    02

    Sun

  • SAN–STL, 08/03/2026: From $620
    03

    Mon

  • SAN–STL, 08/04/2026: From $620
    04

    Tue

  • SAN–STL, 08/05/2026: From $538
    05

    Wed

  • SAN–STL, 08/06/2026: From $538
    06

    Thu

  • SAN–STL, 08/07/2026: From $533
    07

    Fri

  • SAN–STL, 08/08/2026: From $538
    08

    Sat

  • SAN–STL, 08/09/2026: From $538
    09

    Sun

  • SAN–STL, 08/10/2026: From $538
    10

    Mon

  • SAN–STL, 08/11/2026: From $538
    11

    Tue

  • SAN–STL, 08/12/2026: From $538
    12

    Wed

  • SAN–STL, 08/13/2026: From $380
    13

    Thu

  • SAN–STL, 08/14/2026: From $375
    14

    Fri

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    15

    Sat

  • SAN–STL, 08/16/2026: From $380
    16

    Sun

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    17

    Mon

  • SAN–STL, 08/18/2026: From $380
    18

    Tue

  • SAN–STL, 08/19/2026: From $380
    19

    Wed

  • SAN–STL, 08/20/2026: From $184
    20

    Thu

  • SAN–STL, 08/21/2026: From $205
    21

    Fri

  • SAN–STL, 08/22/2026: From $184
    22

    Sat

  • SAN–STL, 08/23/2026: From $274
    23

    Sun

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    24

    Mon

  • SAN–STL, 08/25/2026: From $199
    25

    Tue

  • SAN–STL, 08/26/2026: From $199
    26

    Wed

  • SAN–STL, 08/27/2026: From $184
    27

    Thu

  • SAN–STL, 08/28/2026: From $205
    28

    Fri

  • SAN–STL, 08/29/2026: From $179
    29

    Sat

  • SAN–STL, 08/30/2026: From $248
    30

    Sun

    • Range$179-$620

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    San Diego International Airport
    Arriving at:
    Lambert-St Louis Int'l Airport
    Average flight time:
    3 hours 39 minutes
    Distance:
    1557 miles

    Route Information

    156† Weekly flights
    • 1‡ Nonstop flight per day Monday through Friday
    • 1‡ Nonstop flight on Saturday
    • 2‡ Nonstop flights on Sunday

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    The average flight time from San Diego to St. Louis is 3 hours 39 minutes.
    There are 156 weekly flights from San Diego to St. Louis on Southwest Airlines.
    Yes, Southwest flies nonstop from San Diego to St. Louis once per day from Monday through Friday.
    Yes, Southwest flies nonstop from San Diego to St. Louis once per day on Saturdays and 2 times per day on Sundays.
    To find the lowest fares by day and time to fly San Diego to St. Louis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
    Yes! Flights from San Diego to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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