Southwest® flights from San Diego to St. Louis from $176

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Low fares from San Diego to St. Louis

$

San Diego (SAN)to

St. Louis (STL)
Depart: 12/08/2026

One-way

Basic

From
$176
Seen: 15 hrs ago

San Diego (SAN)to

St. Louis (STL)
Depart: 11/18/2026

One-way

Basic

From
$176
Seen: 7 hrs ago

San Diego (SAN)to

St. Louis (STL)
Depart: 12/09/2026

One-way

Basic

From
$176
Seen: 5 hrs ago

San Diego (SAN)to

St. Louis (STL)
Depart: 12/15/2026

One-way

Basic

From
$176
Seen: 5 hrs ago

San Diego (SAN)to

St. Louis (STL)
Depart: 11/10/2026

One-way

Basic

From
$176
Seen: 6 hrs ago

San Diego (SAN)to

St. Louis (STL)
Depart: 11/26/2026

One-way

Basic

From
$176
Seen: 19 hrs ago

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Explore flights from San Diego to St. Louis

Sep 2026
From$630*
Seen: 6 hrs ago
One Way/Basic
Oct 2026
From$181*
Seen: 19 hrs ago
One Way/Basic
Nov 2026
From$176*
Seen: 6 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $181
cmp-daily-histogram-bars-legend-max-price-aria-label $630
Displaying fares for September-2026
  • SAN–STL, 09/30/2026: From $630
    30

    Wed

    SEP

  • SAN–STL, 10/01/2026: From $630
    01

    Thu

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    02

    Fri

  • SAN–STL, 10/03/2026: From $630
    03

    Sat

  • SAN–STL, 10/04/2026: From $630
    04

    Sun

  • SAN–STL, 10/05/2026: From $630
    05

    Mon

  • SAN–STL, 10/06/2026: From $548
    06

    Tue

  • SAN–STL, 10/07/2026: From $548
    07

    Wed

  • SAN–STL, 10/08/2026: From $548
    08

    Thu

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    09

    Fri

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    10

    Sat

  • SAN–STL, 10/11/2026: From $548
    11

    Sun

  • SAN–STL, 10/12/2026: From $548
    12

    Mon

  • SAN–STL, 10/13/2026: From $390
    13

    Tue

  • SAN–STL, 10/14/2026: From $390
    14

    Wed

  • SAN–STL, 10/15/2026: From $390
    15

    Thu

  • SAN–STL, 10/16/2026: From $390
    16

    Fri

  • SAN–STL, 10/17/2026: From $390
    17

    Sat

  • SAN–STL, 10/18/2026: From $390
    18

    Sun

  • SAN–STL, 10/19/2026: From $390
    19

    Mon

  • SAN–STL, 10/20/2026: From $181
    20

    Tue

  • SAN–STL, 10/21/2026: From $181
    21

    Wed

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    22

    Thu

  • SAN–STL, 10/23/2026: From $210
    23

    Fri

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    24

    Sat

  • SAN–STL, 10/25/2026: From $324
    25

    Sun

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    26

    Mon

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    27

    Tue

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    28

    Wed

  • SAN–STL: cmp-view-offers-disclaimer. Find Offers
    29

    Thu

    • Range$181-$630

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    San Diego International Airport
    Arriving at:
    Lambert-St Louis Int'l Airport
    Average flight time:
    3 hours 39 minutes
    Distance:
    1557 miles

    Route Information

    156† Weekly flights
    • 1‡ Nonstop flight per day Monday through Friday
    • 1‡ Nonstop flight on Saturday
    • 2‡ Nonstop flights on Sunday

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    The average flight time from San Diego to St. Louis is 3 hours 39 minutes.
    There are 156 weekly flights from San Diego to St. Louis on Southwest Airlines.
    Yes, Southwest flies nonstop from San Diego to St. Louis once per day from Monday through Friday.
    Yes, Southwest flies nonstop from San Diego to St. Louis once per day on Saturdays and 2 times per day on Sundays.
    To find the lowest fares by day and time to fly San Diego to St. Louis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
    Yes! Flights from San Diego to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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