Southwest® flights from Des Moines to Greenville-Spartanburg from $225

Promo Code

Low fares from Des Moines to Greenville-Spartanburg

$

Des Moines (DSM)to

Greenville-Spartanburg (GSP)
Depart: 03/19/2026

One-way

Basic

From
$225
Seen: 2 hrs ago

Des Moines (DSM)to

Greenville-Spartanburg (GSP)
Depart: 03/18/2026

One-way

Basic

From
$227
Seen: 2 hrs ago

Des Moines (DSM)to

Greenville-Spartanburg (GSP)
Depart: 03/19/2026

One-way

Choice

From
$260
Seen: 2 hrs ago

Des Moines (DSM)to

Greenville-Spartanburg (GSP)
Depart: 03/18/2026

One-way

Choice

From
$262
Seen: 2 hrs ago

Des Moines (DSM)to

Greenville-Spartanburg (GSP)
Depart: 03/19/2026

One-way

Choice Preferred

From
$330
Seen: 2 hrs ago

Des Moines (DSM)to

Greenville-Spartanburg (GSP)
Depart: 03/18/2026

One-way

Choice Preferred

From
$332
Seen: 2 hrs ago

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Explore flights from Des Moines to Greenville-Spartanburg

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Des Moines Airport
Arriving at:
Greenville-Spartanburg International Airport
Distance:
772 miles

Route Information

21† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 21 weekly flights from Des Moines to Greenville-Spartanburg on Southwest Airlines.
To find the lowest fares by day and time to fly Des Moines to Greenville-Spartanburg with Southwest, check out our Low Fare Calendar.
You can rent a car at Greenville-Spartanburg International Airport book yours with your flight.
Yes! Flights from Des Moines to Greenville-Spartanburg—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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