Southwest® flights from Des Moines to Myrtle Beach from $339

Promo Code

Low fares from Des Moines to Myrtle Beach

$

Des Moines (DSM)to

Myrtle Beach (MYR)
Depart: 04/16/2026

One-way

Basic

From
$339
Seen: 27 minutes ago

Des Moines (DSM)to

Myrtle Beach (MYR)
Depart: 04/16/2026

One-way

Choice

From
$363
Seen: 27 minutes ago

Des Moines (DSM)to

Myrtle Beach (MYR)
Depart: 03/19/2026

One-way

Choice

From
$368
Seen: 10 hrs ago

Des Moines (DSM)to

Myrtle Beach (MYR)
Depart: 03/18/2026

One-way

Choice

From
$399
Seen: 3 hrs ago

Des Moines (DSM)to

Myrtle Beach (MYR)
Depart: 03/19/2026

One-way

Choice Preferred

From
$431
Seen: 10 hrs ago

Des Moines (DSM)to

Myrtle Beach (MYR)
Depart: 04/16/2026

One-way

Choice Preferred

From
$433
Seen: 27 minutes ago

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Explore flights from Des Moines to Myrtle Beach

Mar 2026
From$368*
Seen: 10 hrs ago
One Way/Basic
Apr 2026
From$339*
Seen: 27 minutes ago
One Way/Basic
May 2026
From$444*
Seen: 20 hrs ago
One Way/Basic
$339
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    • Range$339-$399

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Des Moines Airport
    Arriving at:
    Myrtle Beach International Airport
    Distance:
    971 miles

    Route Information

    30† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 30 weekly flights from Des Moines to Myrtle Beach on Southwest Airlines.
    To find the lowest fares by day and time to fly Des Moines to Myrtle Beach with Southwest, check out our Low Fare Calendar.
    You can rent a car at Myrtle Beach International Airport book yours with your flight.
    Yes! Flights from Des Moines to Myrtle Beach—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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