Southwest® flights from Midland/Odessa to Des Moines from $204

Promo Code

Low fares from Midland/Odessa to Des Moines

$

Midland/Odessa (MAF)to

Des Moines (DSM)
Depart: 03/25/2026

One-way

Basic

From
$204
Seen: 22 hrs ago

Midland/Odessa (MAF)to

Des Moines (DSM)
Depart: 04/10/2026

One-way

Basic

From
$207
Seen: 10 hrs ago

Midland/Odessa (MAF)to

Des Moines (DSM)
Depart: 03/24/2026

One-way

Basic

From
$209
Seen: 22 hrs ago

Midland/Odessa (MAF)to

Des Moines (DSM)
Depart: 03/25/2026

One-way

Choice

From
$239
Seen: 22 hrs ago

Midland/Odessa (MAF)to

Des Moines (DSM)
Depart: 04/10/2026

One-way

Choice

From
$244
Seen: 10 hrs ago

Midland/Odessa (MAF)to

Des Moines (DSM)
Depart: 03/24/2026

One-way

Choice

From
$244
Seen: 22 hrs ago

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Explore flights from Midland/Odessa to Des Moines

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Midland International Airport
Arriving at:
Des Moines Airport
Distance:
813 miles

Route Information

34† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 34 weekly flights from Midland/Odessa to Des Moines on Southwest Airlines.
To find the lowest fares by day and time to fly Midland/Odessa to Des Moines with Southwest, check out our Low Fare Calendar.
You can rent a car at Des Moines Airport book yours with your flight.
Yes! Flights from Midland/Odessa to Des Moines—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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