Southwest® flights from Myrtle Beach to Panama City Beach, FL from $224

Promo Code

Low fares from Myrtle Beach to Panama City Beach, FL

$

Myrtle Beach (MYR)to

Panama City Beach, FL (ECP)
Depart: 04/19/2026

One-way

Basic

From
$224
Seen: 8 hrs ago

Myrtle Beach (MYR)to

Panama City Beach, FL (ECP)
Depart: 04/19/2026

One-way

Choice

From
$254
Seen: 8 hrs ago

Myrtle Beach (MYR)to

Panama City Beach, FL (ECP)
Depart: 04/23/2026

One-way

Basic

From
$268
Seen: 7 hrs ago

Myrtle Beach (MYR)to

Panama City Beach, FL (ECP)
Depart: 03/02/2026

One-way

Basic

From
$276
Seen: 19 hrs ago

Myrtle Beach (MYR)to

Panama City Beach, FL (ECP)
Depart: 03/02/2026

One-way

Choice

From
$276
Seen: 19 hrs ago

Myrtle Beach (MYR)to

Panama City Beach, FL (ECP)
Depart: 04/23/2026

One-way

Choice

From
$294
Seen: 7 hrs ago

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Explore flights from Myrtle Beach to Panama City Beach, FL

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Myrtle Beach International Airport
Arriving at:
Northwest Florida Beaches International Airport
Distance:
463 miles

Route Information

41† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 41 weekly flights from Myrtle Beach to Panama City Beach, FL on Southwest Airlines.
To find the lowest fares by day and time to fly Myrtle Beach to Panama City Beach, FL with Southwest, check out our Low Fare Calendar.
You can rent a car at Northwest Florida Beaches International Airport book yours with your flight.
Yes! Flights from Myrtle Beach to Panama City Beach, FL—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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