Southwest® flights from Myrtle Beach to San Francisco from $208

Promo Code

Low fares from Myrtle Beach to San Francisco

$

Myrtle Beach (MYR)to

San Francisco (SFO)
Depart: 04/08/2026

One-way

Basic

From
$208
Seen: 6 hrs ago

Myrtle Beach (MYR)to

San Francisco (SFO)
Depart: 04/08/2026

One-way

Choice

From
$248
Seen: 6 hrs ago

Myrtle Beach (MYR)to

San Francisco (SFO)
Depart: 04/08/2026

One-way

Choice Preferred

From
$328
Seen: 6 hrs ago

Myrtle Beach (MYR)to

San Francisco (SFO)
Depart: 04/11/2026

One-way

Basic

From
$359
Seen: 2 hrs ago

Myrtle Beach (MYR)to

San Francisco (SFO)
Depart: 04/08/2026

One-way

Choice Extra

From
$388
Seen: 6 hrs ago

Myrtle Beach (MYR)to

San Francisco (SFO)
Depart: 04/11/2026

One-way

Choice

From
$389
Seen: 2 hrs ago

Looking for more low-fare flights?

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Explore flights from Myrtle Beach to San Francisco

Mar 2026
From$459*
Seen: 22 hrs ago
One Way/Basic
Apr 2026
From$208*
Seen: 6 hrs ago
One Way/Basic
May 2026
No result for this month.
$208
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    • Range$208-$488

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Myrtle Beach International Airport
    Arriving at:
    San Francisco International Airport
    Distance:
    2438 miles

    Route Information

    53† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 53 weekly flights from Myrtle Beach to San Francisco on Southwest Airlines.
    To find the lowest fares by day and time to fly Myrtle Beach to San Francisco with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Francisco International Airport book yours with your flight.
    Yes! Flights from Myrtle Beach to San Francisco—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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