Southwest® flights from Panama City Beach, FL to San Francisco from $249

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Low fares from Panama City Beach, FL to San Francisco

$

Panama City Beach, FL (ECP)to

San Francisco (SFO)
Depart: 06/04/2026

One-way

Basic

From
$219
Seen: 7 hrs ago

Panama City Beach, FL (ECP)to

San Francisco (SFO)
Depart: 05/23/2026

One-way

Basic

From
$249
Seen: 18 hrs ago

Panama City Beach, FL (ECP)to

San Francisco (SFO)
Depart: 06/04/2026

One-way

Choice

From
$259
Seen: 7 hrs ago

Panama City Beach, FL (ECP)to

San Francisco (SFO)
Depart: 05/23/2026

One-way

Choice

From
$289
Seen: 18 hrs ago

Panama City Beach, FL (ECP)to

San Francisco (SFO)
Depart: 05/03/2026

One-way

Basic

From
$309
Seen: 23 hrs ago

Panama City Beach, FL (ECP)to

San Francisco (SFO)
Depart: 06/04/2026

One-way

Choice Preferred

From
$339
Seen: 7 hrs ago

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Explore flights from Panama City Beach, FL to San Francisco

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Northwest Florida Beaches International Airport
Arriving at:
San Francisco International Airport
Distance:
2145 miles

Route Information

46† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 46 weekly flights from Panama City Beach, FL to San Francisco on Southwest Airlines.
To find the lowest fares by day and time to fly Panama City Beach, FL to San Francisco with Southwest, check out our Low Fare Calendar.
You can rent a car at San Francisco International Airport book yours with your flight.
Yes! Flights from Panama City Beach, FL to San Francisco—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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