Southwest® flights from Chicago-Midway to St. Louis from $59
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Low fares from Chicago-Midway to St. Louis
$
Chicago-Midway (MDW)to
St. Louis (STL)
Depart: 11/16/2026
One-way
Basic
From
$59
Seen: 17 hrs ago
Chicago-Midway (MDW)to
St. Louis (STL)
Depart: 10/20/2026
One-way
Basic
From
$59
Seen: 19 hrs ago
Chicago-Midway (MDW)to
St. Louis (STL)
Depart: 10/27/2026
One-way
Basic
From
$59
Seen: 20 hrs ago
Chicago-Midway (MDW)to
St. Louis (STL)
Depart: 12/05/2026
One-way
Basic
From
$59
Seen: 11 hrs ago
Chicago-Midway (MDW)to
St. Louis (STL)
Depart: 11/04/2026
One-way
Basic
From
$59
Seen: 12 hrs ago
Chicago-Midway (MDW)to
St. Louis (STL)
Depart: 11/02/2026
One-way
Basic
From
$59
Seen: 17 hrs ago
Explore flights from Chicago-Midway to St. Louis
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Flight Details
Departing from:
Chicago Midway International Airport
Arriving at:
Lambert-St Louis Int'l Airport
Average flight time:
1 hour 11 minutes
Distance:
251 miles
Route Information
156† Weekly flights
- 4‡ Nonstop flights per day Monday through Friday
- 3‡ Nonstop flights on Saturday
- 4‡ Nonstop flights on Sunday
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Explore St. Louis
There might be nothing more famous in St. Louis than the arch on the Mississippi. Officially known as the Gateway Arch, it was built in the 1960s and stands at 630 feet tall. The arch helps to honor Lewis and Clark’s 19th-century explorations as well as the expansion to the West. Visit the Museum at the Gateway Arch, a National Park landmark, and learn about the Louisiana Purchase, the Dred Scott case, and more.
You may be coming from the home of deep dish pizza, but did you know that St. Louis is known for its own style of pizza? Its sauce features more oregano than other types of pizza, and the pizza is frequently made with Provel cheese, a type of processed cheese that combines provolone, Swiss, and white cheddar. With a thin, cracker-like crust, Provel cheese, and square slices, you may find yourself flying back to St. Louis more frequently thanks to this unique style of pizza.
Questions we hear the most
The average flight time from Chicago (Midway) to St. Louis is 1 hour 11 minutes.
There are 156 weekly flights from Chicago (Midway) to St. Louis on Southwest Airlines.
Yes, Southwest flies nonstop from Chicago (Midway) to St. Louis 4 times per day from Monday through Friday.
Yes, Southwest flies nonstop from Chicago (Midway) to St. Louis 3 times per day on Saturdays and 4 times per day on Sundays.
To find the lowest fares by day and time to fly Chicago (Midway) to St. Louis with Southwest, check out our Low Fare Calendar.
You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
Yes! Flights from Chicago (Midway) to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.
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