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Find low faresSouthwest® flights from Fort Myers/Naples to St. Louis from $160
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1 Passenger
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Low fares from Fort Myers/Naples to St. Louis
$
Fort Myers/Naples (RSW)to
St. Louis (STL)
Depart: 03/03/2026
One-way
Basic
From
$160
Seen: 18 hrs ago
Fort Myers/Naples (RSW)to
St. Louis (STL)
Depart: 02/26/2026
One-way
Basic
From
$160
Seen: 15 hrs ago
Fort Myers/Naples (RSW)to
St. Louis (STL)
Depart: 03/07/2026
One-way
Basic
From
$161
Seen: 10 hrs ago
Fort Myers/Naples (RSW)to
St. Louis (STL)
Depart: 03/14/2026
One-way
Basic
From
$161
Seen: 6 hrs ago
Fort Myers/Naples (RSW)to
St. Louis (STL)
Depart: 02/25/2026
One-way
Basic
From
$170
Seen: 17 hrs ago
Fort Myers/Naples (RSW)to
St. Louis (STL)
Depart: 02/14/2026
One-way
Basic
From
$170
Seen: 6 hrs ago
Explore flights from Fort Myers/Naples to St. Louis
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Flight Details
Departing from:
Southwest Florida Regional Airport
Arriving at:
Lambert-St Louis Int'l Airport
Average flight time:
2 hours 36 minutes
Distance:
979 miles
Route Information
145† Weekly flights
- 2‡ Nonstop flights per day Monday through Friday
- 2‡ Nonstop flights on Saturday
- 3‡ Nonstop flights on Sunday
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
The average flight time from Fort Myers/Naples to St. Louis is 2 hours 36 minutes.
There are 145 weekly flights from Fort Myers/Naples to St. Louis on Southwest Airlines.
Yes, Southwest flies nonstop from Fort Myers/Naples to St. Louis 2 times per day from Monday through Friday.
Yes, Southwest flies nonstop from Fort Myers/Naples to St. Louis 2 times per day on Saturdays and 3 times per day on Sundays.
To find the lowest fares by day and time to fly Fort Myers/Naples to St. Louis with Southwest, check out our Low Fare Calendar.
You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
Yes! Flights from Fort Myers/Naples to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.