Southwest® flights from Harlingen/South Padre Island to Des Moines from $153

Promo Code

Low fares from Harlingen/South Padre Island to Des Moines

$

Harlingen/South Padre Island (HRL)to

Des Moines (DSM)
Depart: 09/02/2026

One-way

Basic

From
$153
Seen: 23 hrs ago

Harlingen/South Padre Island (HRL)to

Des Moines (DSM)
Depart: 08/29/2026

One-way

Basic

From
$170
Seen: 21 hrs ago

Harlingen/South Padre Island (HRL)to

Des Moines (DSM)
Depart: 09/01/2026

One-way

Basic

From
$170
Seen: 13 hrs ago

Harlingen/South Padre Island (HRL)to

Des Moines (DSM)
Depart: 09/02/2026

One-way

Choice

From
$198
Seen: 23 hrs ago

Harlingen/South Padre Island (HRL)to

Des Moines (DSM)
Depart: 09/01/2026

One-way

Choice

From
$215
Seen: 13 hrs ago

Harlingen/South Padre Island (HRL)to

Des Moines (DSM)
Depart: 08/29/2026

One-way

Choice

From
$215
Seen: 21 hrs ago

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Explore flights from Harlingen/South Padre Island to Des Moines

Aug 2026
From$170*
Seen: 21 hrs ago
One Way/Basic
Sep 2026
From$153*
Seen: 23 hrs ago
One Way/Basic
Oct 2026
No result for this month.
cmp-daily-histogram-bars-legend-min-price-aria-label $153
Displaying fares for August-2026
  • HRL–DSM, 08/05/2026: From $585
    05

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  • HRL–DSM, 08/14/2026: From $455
    14

    Fri

  • HRL–DSM, 08/15/2026: From $329
    15

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    Fri

  • HRL–DSM, 08/29/2026: From $170
    29

    Sat

  • HRL–DSM, 08/30/2026: From $285
    30

    Sun

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    31

    Mon

  • HRL–DSM, 09/01/2026: From $170
    01

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    SEP

  • HRL–DSM, 09/02/2026: From $153
    02

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    • Range$153-$585

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Valley International Airport
    Arriving at:
    Des Moines Airport
    Distance:
    1079 miles

    Route Information

    28† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 28 weekly flights from Harlingen/South Padre Island to Des Moines on Southwest Airlines.
    To find the lowest fares by day and time to fly Harlingen/South Padre Island to Des Moines with Southwest, check out our Low Fare Calendar.
    You can rent a car at Des Moines Airport book yours with your flight.
    Yes! Flights from Harlingen/South Padre Island to Des Moines—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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