Southwest® flights from Indianapolis to San Francisco from $180

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Low fares from Indianapolis to San Francisco

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Indianapolis (IND)to

San Francisco (SFO)
Depart: 09/26/2026

One-way

Basic

From
$180
Seen: 20 hrs ago

Indianapolis (IND)to

San Francisco (SFO)
Depart: 09/17/2026

One-way

Basic

From
$180
Seen: 16 hrs ago

Indianapolis (IND)to

San Francisco (SFO)
Depart: 09/23/2026

One-way

Basic

From
$180
Seen: 4 hrs ago

Indianapolis (IND)to

San Francisco (SFO)
Depart: 11/02/2026

One-way

Basic

From
$180
Seen: 6 hrs ago

Indianapolis (IND)to

San Francisco (SFO)
Depart: 11/01/2026

One-way

Basic

From
$180
Seen: 15 hrs ago

Indianapolis (IND)to

San Francisco (SFO)
Depart: 09/15/2026

One-way

Basic

From
$180
Seen: 14 hrs ago

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Explore flights from Indianapolis to San Francisco

Aug 2026
From$326*
Seen: 18 hrs ago
One Way/Basic
Sep 2026
From$180*
Seen: 14 hrs ago
One Way/Basic
Oct 2026
From$180*
Seen: 33 minutes ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $180
cmp-daily-histogram-bars-legend-max-price-aria-label $340
Displaying fares for August-2026
  • IND–SFO, 08/22/2026: From $340
    22

    Sat

    AUG

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    23

    Sun

  • IND–SFO, 08/24/2026: From $340
    24

    Mon

  • IND–SFO, 08/25/2026: From $326
    25

    Tue

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    26

    Wed

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    27

    Thu

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    28

    Fri

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    29

    Sat

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    30

    Sun

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    31

    Mon

  • IND–SFO, 09/01/2026: From $275
    01

    Tue

    SEP

  • IND–SFO, 09/02/2026: From $275
    02

    Wed

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    03

    Thu

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    04

    Fri

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    05

    Sat

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    06

    Sun

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    07

    Mon

  • IND–SFO, 09/08/2026: From $259
    08

    Tue

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    09

    Wed

  • IND–SFO, 09/10/2026: From $215
    10

    Thu

  • IND–SFO, 09/11/2026: From $180
    11

    Fri

  • IND–SFO, 09/12/2026: From $180
    12

    Sat

  • IND–SFO, 09/13/2026: From $214
    13

    Sun

  • IND–SFO, 09/14/2026: From $180
    14

    Mon

  • IND–SFO, 09/15/2026: From $180
    15

    Tue

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    16

    Wed

  • IND–SFO, 09/17/2026: From $180
    17

    Thu

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    18

    Fri

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    19

    Sat

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    20

    Sun

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    21

    Mon

    • Range$180-$340

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Indianapolis International Airport
    Arriving at:
    San Francisco International Airport
    Distance:
    1943 miles

    Route Information

    151† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 151 weekly flights from Indianapolis to San Francisco on Southwest Airlines.
    To find the lowest fares by day and time to fly Indianapolis to San Francisco with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Francisco International Airport book yours with your flight.
    Yes! Flights from Indianapolis to San Francisco—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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