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Find low faresSouthwest® flights from Jacksonville to Louisville from $149
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Low fares from Jacksonville to Louisville
$
Jacksonville (JAX)to
Louisville (SDF)
Depart: 04/07/2026
One-way
Basic
From
$149
Seen: 15 hrs ago
Jacksonville (JAX)to
Louisville (SDF)
Depart: 04/21/2026
One-way
Basic
From
$149
Seen: 19 hrs ago
Jacksonville (JAX)to
Louisville (SDF)
Depart: 03/09/2026
One-way
Basic
From
$161
Seen: 17 hrs ago
Jacksonville (JAX)to
Louisville (SDF)
Depart: 02/21/2026
One-way
Basic
From
$161
Seen: 16 hrs ago
Jacksonville (JAX)to
Louisville (SDF)
Depart: 04/23/2026
One-way
Basic
From
$161
Seen: 23 hrs ago
Jacksonville (JAX)to
Louisville (SDF)
Depart: 03/12/2026
One-way
Basic
From
$161
Seen: 20 hrs ago
Explore flights from Jacksonville to Louisville
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Flight Details
Departing from:
Jacksonville International Airport
Arriving at:
Louisville International Airport
Distance:
578 miles
Route Information
74† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 74 weekly flights from Jacksonville to Louisville on Southwest Airlines.
To find the lowest fares by day and time to fly Jacksonville to Louisville with Southwest, check out our Low Fare Calendar.
You can rent a car at Louisville International Airport book yours with your flight.
Yes! Flights from Jacksonville to Louisville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.