Looking for more low-fare flights?
Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.
Find low faresSouthwest® flights from Jacksonville to St. Louis from $129
expand_more
1 Passenger
expand_morePromo Code
expand_moretoday
today
Low fares from Jacksonville to St. Louis
$
Jacksonville (JAX)to
St. Louis (STL)
Depart: 03/04/2026
One-way
Basic
From
$129
Seen: 22 hrs ago
Jacksonville (JAX)to
St. Louis (STL)
Depart: 03/10/2026
One-way
Basic
From
$129
Seen: 22 hrs ago
Jacksonville (JAX)to
St. Louis (STL)
Depart: 03/03/2026
One-way
Basic
From
$129
Seen: 22 hrs ago
Jacksonville (JAX)to
St. Louis (STL)
Depart: 03/25/2026
One-way
Basic
From
$129
Seen: 23 hrs ago
Jacksonville (JAX)to
St. Louis (STL)
Depart: 03/11/2026
One-way
Basic
From
$129
Seen: 21 hrs ago
Jacksonville (JAX)to
St. Louis (STL)
Depart: 04/01/2026
One-way
Basic
From
$129
Seen: 15 hrs ago
Explore flights from Jacksonville to St. Louis
location_on
location_on
Flight Details
Departing from:
Jacksonville International Airport
Arriving at:
Lambert-St Louis Int'l Airport
Average flight time:
2 hours 10 minutes
Distance:
753 miles
Route Information
128† Weekly flights
- 2‡ Nonstop flights per day Monday through Friday
- 1‡ Nonstop flight on Saturday
- 2‡ Nonstop flights on Sunday
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
The average flight time from Jacksonville to St. Louis is 2 hours 10 minutes.
There are 128 weekly flights from Jacksonville to St. Louis on Southwest Airlines.
Yes, Southwest flies nonstop from Jacksonville to St. Louis 2 times per day from Monday through Friday.
Yes, Southwest flies nonstop from Jacksonville to St. Louis once per day on Saturdays and 2 times per day on Sundays.
To find the lowest fares by day and time to fly Jacksonville to St. Louis with Southwest, check out our Low Fare Calendar.
You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
Yes! Flights from Jacksonville to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.