Southwest® flights from Pensacola to Des Moines from $168

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Low fares from Pensacola to Des Moines

$

Pensacola (PNS)to

Des Moines (DSM)
Depart: 01/07/2027

One-way

Basic

From
$168
Seen: 23 hrs ago

Pensacola (PNS)to

Des Moines (DSM)
Depart: 01/07/2027

One-way

Choice

From
$208
Seen: 23 hrs ago

Pensacola (PNS)to

Des Moines (DSM)
Depart: 12/22/2026

One-way

Basic

From
$214
Seen: 6 hrs ago

Pensacola (PNS)to

Des Moines (DSM)
Depart: 12/22/2026

One-way

Choice

From
$254
Seen: 6 hrs ago

Pensacola (PNS)to

Des Moines (DSM)
Depart: 10/14/2026

One-way

Basic

From
$272
Seen: 22 hrs ago

Pensacola (PNS)to

Des Moines (DSM)
Depart: 01/07/2027

One-way

Choice Preferred

From
$278
Seen: 23 hrs ago

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Explore flights from Pensacola to Des Moines

Oct 2026
From$272*
Seen: 22 hrs ago
One Way/Basic
Nov 2026
No result for this month.
Dec 2026
From$214*
Seen: 6 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $272
Displaying fares for October-2026
  • PNS–DSM: cmp-view-offers-disclaimer. Find Offers
    12

    Mon

    OCT

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    13

    Tue

  • PNS–DSM, 10/14/2026: From $272
    14

    Wed

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    15

    Thu

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    16

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    17

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    18

    Sun

  • PNS–DSM, 10/19/2026: From $312
    19

    Mon

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    20

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    21

    Wed

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    22

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    23

    Fri

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    24

    Sat

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    25

    Sun

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    26

    Mon

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    27

    Tue

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    28

    Wed

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    29

    Thu

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    30

    Fri

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    31

    Sat

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    01

    Sun

    NOV

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    02

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    03

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    04

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    05

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    06

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    07

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    08

    Sun

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    09

    Mon

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    10

    Tue

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    11

    Wed

    • Range$272-$312

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Pensacola International Airport
    Arriving at:
    Des Moines Airport
    Distance:
    844 miles

    Questions we hear the most

    There are 32 weekly flights from Pensacola to Des Moines on Southwest Airlines.
    To find the lowest fares by day and time to fly Pensacola to Des Moines with Southwest, check out our Low Fare Calendar.
    You can rent a car at Des Moines Airport book yours with your flight.
    Yes! Flights from Pensacola to Des Moines—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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