Southwest® flights from Pittsburgh to Des Moines from $384

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Low fares from Pittsburgh to Des Moines

$

Pittsburgh (PIT)to

Des Moines (DSM)
Depart: 02/21/2026

One-way

Choice

From
$384
Seen: 16 hrs ago

Pittsburgh (PIT)to

Des Moines (DSM)
Depart: 03/20/2026

One-way

Choice

From
$428
Seen: 16 hrs ago

Pittsburgh (PIT)to

Des Moines (DSM)
Depart: 02/21/2026

One-way

Choice Preferred

From
$454
Seen: 16 hrs ago

Pittsburgh (PIT)to

Des Moines (DSM)
Depart: 03/20/2026

One-way

Choice Preferred

From
$498
Seen: 16 hrs ago

Pittsburgh (PIT)to

Des Moines (DSM)
Depart: 02/21/2026

One-way

Choice Extra

From
$504
Seen: 16 hrs ago

Pittsburgh (PIT)to

Des Moines (DSM)
Depart: 03/20/2026

One-way

Choice Extra

From
$548
Seen: 16 hrs ago

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Explore flights from Pittsburgh to Des Moines

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Pittsburgh International Airport
Arriving at:
Des Moines Airport
Distance:
705 miles

Route Information

39† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 39 weekly flights from Pittsburgh to Des Moines on Southwest Airlines.
To find the lowest fares by day and time to fly Pittsburgh to Des Moines with Southwest, check out our Low Fare Calendar.
You can rent a car at Des Moines Airport book yours with your flight.
Yes! Flights from Pittsburgh to Des Moines—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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