Southwest® flights from Portland, OR to Des Moines from $229

Promo Code

Low fares from Portland, OR to Des Moines

$

Portland, OR (PDX)to

Des Moines (DSM)
Depart: 12/02/2026

One-way

Basic

From
$229
Seen: 4 hrs ago

Portland, OR (PDX)to

Des Moines (DSM)
Depart: 12/10/2026

One-way

Basic

From
$229
Seen: 8 hrs ago

Portland, OR (PDX)to

Des Moines (DSM)
Depart: 02/12/2027

One-way

Basic

From
$229
Seen: 1 hour ago

Portland, OR (PDX)to

Des Moines (DSM)
Depart: 12/11/2026

One-way

Basic

From
$229
Seen: 1 hour ago

Portland, OR (PDX)to

Des Moines (DSM)
Depart: 02/14/2027

One-way

Basic

From
$244
Seen: 15 hrs ago

Portland, OR (PDX)to

Des Moines (DSM)
Depart: 12/17/2026

One-way

Basic

From
$244
Seen: 23 hrs ago

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Explore flights from Portland, OR to Des Moines

Nov 2026
From$314*
Seen: 8 hrs ago
One Way/Basic
Dec 2026
From$229*
Seen: 1 hour ago
One Way/Basic
Jan 2027
No result for this month.
cmp-daily-histogram-bars-legend-min-price-aria-label $229
cmp-daily-histogram-bars-legend-max-price-aria-label $574
Displaying fares for November-2026
  • PDX–DSM, 11/12/2026: From $574
    12

    Thu

    NOV

  • PDX–DSM, 11/13/2026: From $574
    13

    Fri

  • PDX–DSM: cmp-view-offers-disclaimer. Find Offers
    14

    Sat

  • PDX–DSM: cmp-view-offers-disclaimer. Find Offers
    15

    Sun

  • PDX–DSM: cmp-view-offers-disclaimer. Find Offers
    16

    Mon

  • PDX–DSM, 11/17/2026: From $574
    17

    Tue

  • PDX–DSM: cmp-view-offers-disclaimer. Find Offers
    18

    Wed

  • PDX–DSM, 11/19/2026: From $489
    19

    Thu

  • PDX–DSM, 11/20/2026: From $489
    20

    Fri

  • PDX–DSM, 11/21/2026: From $489
    21

    Sat

  • PDX–DSM, 11/22/2026: From $489
    22

    Sun

  • PDX–DSM, 11/23/2026: From $489
    23

    Mon

  • PDX–DSM, 11/24/2026: From $489
    24

    Tue

  • PDX–DSM: cmp-view-offers-disclaimer. Find Offers
    25

    Wed

  • PDX–DSM, 11/26/2026: From $314
    26

    Thu

  • PDX–DSM, 11/27/2026: From $314
    27

    Fri

  • PDX–DSM, 11/28/2026: From $372
    28

    Sat

  • PDX–DSM, 11/29/2026: From $499
    29

    Sun

  • PDX–DSM, 11/30/2026: From $335
    30

    Mon

  • PDX–DSM, 12/01/2026: From $314
    01

    Tue

    DEC

  • PDX–DSM, 12/02/2026: From $229
    02

    Wed

  • PDX–DSM: cmp-view-offers-disclaimer. Find Offers
    03

    Thu

  • PDX–DSM: cmp-view-offers-disclaimer. Find Offers
    04

    Fri

  • PDX–DSM: cmp-view-offers-disclaimer. Find Offers
    05

    Sat

  • PDX–DSM: cmp-view-offers-disclaimer. Find Offers
    06

    Sun

  • PDX–DSM: cmp-view-offers-disclaimer. Find Offers
    07

    Mon

  • PDX–DSM: cmp-view-offers-disclaimer. Find Offers
    08

    Tue

  • PDX–DSM: cmp-view-offers-disclaimer. Find Offers
    09

    Wed

  • PDX–DSM, 12/10/2026: From $229
    10

    Thu

  • PDX–DSM, 12/11/2026: From $229
    11

    Fri

    • Range$229-$574

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Portland International Airport
    Arriving at:
    Des Moines Airport
    Distance:
    1471 miles

    Questions we hear the most

    There are 55 weekly flights from Portland, OR to Des Moines on Southwest Airlines.
    To find the lowest fares by day and time to fly Portland, OR to Des Moines with Southwest, check out our Low Fare Calendar.
    You can rent a car at Des Moines Airport book yours with your flight.
    Yes! Flights from Portland, OR to Des Moines—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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