Southwest® flights from San Diego to Des Moines from $178

Promo Code

Low fares from San Diego to Des Moines

$

San Diego (SAN)to

Des Moines (DSM)
Depart: 10/03/2026

One-way

Basic

From
$178
Seen: 11 hrs ago

San Diego (SAN)to

Des Moines (DSM)
Depart: 11/18/2026

One-way

Basic

From
$178
Seen: 3 hrs ago

San Diego (SAN)to

Des Moines (DSM)
Depart: 10/13/2026

One-way

Basic

From
$178
Seen: 1 hour ago

San Diego (SAN)to

Des Moines (DSM)
Depart: 10/27/2026

One-way

Basic

From
$178
Seen: 5 hrs ago

San Diego (SAN)to

Des Moines (DSM)
Depart: 10/05/2026

One-way

Basic

From
$178
Seen: 8 hrs ago

San Diego (SAN)to

Des Moines (DSM)
Depart: 10/14/2026

One-way

Basic

From
$178
Seen: 3 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from San Diego to Des Moines

Sep 2026
From$284*
Seen: 1 hour ago
One Way/Basic
Oct 2026
From$178*
Seen: 11 hrs ago
One Way/Basic
Nov 2026
From$178*
Seen: 3 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $178
cmp-daily-histogram-bars-legend-max-price-aria-label $549
Displaying fares for September-2026
  • SAN–DSM, 09/10/2026: From $549
    10

    Thu

    SEP

  • SAN–DSM, 09/11/2026: From $549
    11

    Fri

  • SAN–DSM, 09/12/2026: From $544
    12

    Sat

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    13

    Sun

  • SAN–DSM, 09/14/2026: From $549
    14

    Mon

  • SAN–DSM, 09/15/2026: From $549
    15

    Tue

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    16

    Wed

  • SAN–DSM, 09/17/2026: From $464
    17

    Thu

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    18

    Fri

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    19

    Sat

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    20

    Sun

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    21

    Mon

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    22

    Tue

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    23

    Wed

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    24

    Thu

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    25

    Fri

  • SAN–DSM, 09/26/2026: From $284
    26

    Sat

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    27

    Sun

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    28

    Mon

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    29

    Tue

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    30

    Wed

  • SAN–DSM, 10/01/2026: From $248
    01

    Thu

    OCT

  • SAN–DSM, 10/02/2026: From $203
    02

    Fri

  • SAN–DSM, 10/03/2026: From $178
    03

    Sat

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    04

    Sun

  • SAN–DSM, 10/05/2026: From $178
    05

    Mon

  • SAN–DSM, 10/06/2026: From $183
    06

    Tue

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    07

    Wed

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    08

    Thu

  • SAN–DSM: cmp-view-offers-disclaimer. Find Offers
    09

    Fri

    • Range$178-$549

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    San Diego International Airport
    Arriving at:
    Des Moines Airport
    Distance:
    1428 miles

    Route Information

    68† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 68 weekly flights from San Diego to Des Moines on Southwest Airlines.
    To find the lowest fares by day and time to fly San Diego to Des Moines with Southwest, check out our Low Fare Calendar.
    You can rent a car at Des Moines Airport book yours with your flight.
    Yes! Flights from San Diego to Des Moines—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

    Explore Flights from Other Popular Origins

    Popular Flights from San Diego