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Find low faresSouthwest® flights from Tampa to Des Moines from $160
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Low fares from Tampa to Des Moines
$
Tampa (TPA)to
Des Moines (DSM)
Depart: 03/11/2026
One-way
Basic
From
$160
Seen: 15 hrs ago
Tampa (TPA)to
Des Moines (DSM)
Depart: 04/01/2026
One-way
Basic
From
$180
Seen: 6 hrs ago
Tampa (TPA)to
Des Moines (DSM)
Depart: 04/08/2026
One-way
Basic
From
$180
Seen: 1 hour ago
Tampa (TPA)to
Des Moines (DSM)
Depart: 05/07/2026
One-way
Basic
From
$180
Seen: 4 hrs ago
Tampa (TPA)to
Des Moines (DSM)
Depart: 02/23/2026
One-way
Basic
From
$200
Seen: 18 hrs ago
Tampa (TPA)to
Des Moines (DSM)
Depart: 03/11/2026
One-way
Choice
From
$200
Seen: 15 hrs ago
Explore flights from Tampa to Des Moines
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Flight Details
Departing from:
Tampa International Airport
Arriving at:
Des Moines Airport
Distance:
1127 miles
Route Information
62† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 62 weekly flights from Tampa to Des Moines on Southwest Airlines.
To find the lowest fares by day and time to fly Tampa to Des Moines with Southwest, check out our Low Fare Calendar.
You can rent a car at Des Moines Airport book yours with your flight.
Yes! Flights from Tampa to Des Moines—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.