Southwest® flights from Des Moines starting at $133
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Book flights from Des Moines with Southwest Airlines
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$
Des Moines (DSM)to
Denver (DEN)Depart: 08/27/2026
From
$133
Seen: 23 hrs ago
One-way
Basic
Des Moines (DSM)to
Houston (Hobby) (HOU)Depart: 07/29/2026
From
$145
Seen: 17 hrs ago
One-way
Basic
Des Moines (DSM)to
Nashville (BNA)Depart: 09/05/2026
From
$149
Seen: 1 hour ago
One-way
Basic
Des Moines (DSM)to
Los Angeles (LAX)Depart: 09/15/2026
From
$153
Seen: 19 hrs ago
One-way
Basic
Des Moines (DSM)to
Long Beach (LGB)Depart: 08/18/2026
From
$153
Seen: 4 hrs ago
One-way
Basic
Des Moines (DSM)to
Philadelphia (PHL)Depart: 08/25/2026
From
$163
Seen: 23 hrs ago
One-way
Basic
Des Moines (DSM)to
Chicago (Midway) (MDW)Depart: 08/15/2026
From
$165
Seen: 19 hrs ago
One-way
Basic
Des Moines (DSM)to
Jacksonville (JAX)Depart: 09/05/2026
From
$172
Seen: 22 hrs ago
One-way
Basic
Des Moines (DSM)to
Pensacola (PNS)Depart: 08/04/2026
From
$173
Seen: 1 hour ago
One-way
Basic
Des Moines (DSM)to
St. Louis (STL)Depart: 07/20/2026
From
$173
Seen: 23 hrs ago
One-way
Basic
Des Moines (DSM)to
Colorado Springs (COS)Depart: 07/29/2026
From
$180
Seen: 1 hour ago
One-way
Basic
Des Moines (DSM)to
Burbank (BUR)Depart: 09/15/2026
From
$186
Seen: 19 hrs ago
One-way
Basic
*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.
Traveling from Des Moines
Southwest Airlines is proud to serve Des Moines International Airport.
Home might be where the heartland is, but Southwest flights out of Des Moines International Airport make it simple to find a change of scenery. No matter how you get to the airport, we make it easy for Iowans to find a great deal on flights and get where they’re going from Des Moines.
Whether you’ve got your sights set on a scenic mountainside getaway or an action-packed adventure in a new city, or you’re ready to warm up or hit the slopes in wintertime, your destination is only a flight away from Des Moines. Swap the Des Moines River for a clear mountain stream beneath the stars or enjoy the bright lights of another bustling big city. Explore the destination options available through Southwest and see which potential getaway really grabs you.
Details about Des Moines Airport
Airport code:
DSM
City:
Des Moines
State:
Iowa
Concourse:
Concourse C
Gates:
Gate C1
Airport-provided WiFi
Cities with weekly flights from DSM:
117†
Cities with daily nonstop flights Monday through Friday from DSM:
4‡
Cities with daily nonstop flights Saturday through Sunday from DSM:
8§
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 10/1/2025 and 10/31/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 10/1/2025 and 10/31/2025.
Popular Destinations from Des Moines
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From | To | Fare Type | Dates | Price | |
|---|---|---|---|---|---|
| Des Moines (DSM) | Denver (DEN) | One-way / Basic | Depart: 08/27/2026 | From $133 Seen: 23 hrs ago | |
| Des Moines (DSM) | Houston (Hobby) (HOU) | One-way / Basic | Depart: 07/29/2026 | From $145 Seen: 17 hrs ago | |
| Des Moines (DSM) | Nashville (BNA) | One-way / Basic | Depart: 09/05/2026 | From $149 Seen: 1 hour ago | |
| Des Moines (DSM) | Los Angeles (LAX) | One-way / Basic | Depart: 08/11/2026 | From $153 Seen: 4 hrs ago | |
| Des Moines (DSM) | Long Beach (LGB) | One-way / Basic | Depart: 08/18/2026 | From $153 Seen: 4 hrs ago | |
| Des Moines (DSM) | Philadelphia (PHL) | One-way / Basic | Depart: 08/25/2026 | From $163 Seen: 23 hrs ago | |
| Des Moines (DSM) | Chicago (Midway) (MDW) | One-way / Basic | Depart: 09/09/2026 | From $165 Seen: 21 hrs ago | |
| Des Moines (DSM) | Pensacola (PNS) | One-way / Basic | Depart: 11/07/2026 | From $167 Seen: 5 hrs ago |
*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.
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12022–2023 Freddie Awards. 2Where available. Available only on WiFi-enabled designated aircraft. Free WiFi is only for Rapid Rewards® Members.
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