Traveling from Orange County/Santa Ana.

Southwest Airlines is proud to serve John Wayne Airport Orange County.

If you are looking to trek north up the California coast or slip the state line and head east, you’ll find convenient flights from Southwest out of Orange County/Santa Ana that get you where you need to go. Likewise, you’ll find a conveniently located launchpad from which to start your next adventure in John Wayne Airport Orange County.

Peruse all of the locations that Southwest Airlines flies from Orange County/Santa Ana to discover destinations for your next trip out of SoCal. Whether you’ve got your sights set on snowcapped mountains or the busy streets of a city away from home, you’ll find a number of options with Southwest.

Southwest makes it simple to trade the same old same old for something new. Plan your next voyage with the help of the list of destinations below. And once you’ve chosen where to travel, you can find add-ons like tours, travel bundles, and exciting activities to enjoy after you’ve arrived. Book your next trip, earn Rapid Rewards® points, and enjoy a straightforward process all the way from booking to boarding. See what else goes into making your trip a memorable one and learn more about the complete Southwest® Experience today.

Other airports in the Los Angeles area.

Want to depart from another airport Southwest serves? Consider booking a flight from Los Angeles International Airport, Long Beach Airport, Hollywood Burbank Airport, or Ontario International Airport.

Where you can fly from Orange County/Santa Ana.

Plan your ideal trip from Orange County/Santa Ana.

Las Vegas

Jet off to America’s Playground! When you travel to Las Vegas, having a good time is a sure thing.

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San Francisco (SFO)

Wade into the adventure that awaits you in Golden Gate City. Enjoy West Coast vibes—book your flight to San Francisco today and get ready to be wowed by the City by the Bay.

Read more about San Francisco (SFO)
San Jose, CA

Immerse yourself in SoCal culture, spend time in the great outdoors, and take in the city’s unique architectural history.

Read more about San Jose, CA

See what life is like in the Valley of the Sun when you fly to Phoenix Sky Harbor International Airport.

Read more about Phoenix