Southwest® flights from Amarillo to Knoxville from $244

Promo Code

Low fares from Amarillo to Knoxville

$

Amarillo (AMA)to

Knoxville (TYS)
Depart: 07/26/2026

One-way

Basic

From
$239

Low fares from Amarillo to Knoxville

$

Amarillo (AMA)to

Knoxville (TYS)
Depart: 04/15/2026

One-way

Basic

From
$244
Seen: 21 hrs ago

Amarillo (AMA)to

Knoxville (TYS)
Depart: 04/15/2026

One-way

Choice

From
$279
Seen: 21 hrs ago

Amarillo (AMA)to

Knoxville (TYS)
Depart: 03/22/2026

One-way

Basic

From
$339
Seen: 7 hrs ago

Amarillo (AMA)to

Knoxville (TYS)
Depart: 04/15/2026

One-way

Choice Preferred

From
$349
Seen: 21 hrs ago

Amarillo (AMA)to

Knoxville (TYS)
Depart: 03/22/2026

One-way

Choice

From
$369
Seen: 7 hrs ago

Amarillo (AMA)to

Knoxville (TYS)
Depart: 04/15/2026

One-way

Choice Extra

From
$394
Seen: 21 hrs ago

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Explore flights from Amarillo to Knoxville

Mar 2026
From$339*
Seen: 7 hrs ago
One Way/Basic
Apr 2026
From$244*
Seen: 21 hrs ago
One Way/Basic
May 2026
No result for this month.
$244
Displaying fares for March-2026
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    • Range$244-$339

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Rick Husband Amarillo International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    998 miles

    Route Information

    30† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 30 weekly flights from Amarillo to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Amarillo to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Amarillo to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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