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Find low faresSouthwest® flights from Des Moines starting at $49
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Book flights from Des Moines with Southwest Airlines
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$
Des Moines (DSM)to
St. Louis (STL)Depart: 02/24/2026
From
$49
Seen: 19 hrs ago
One-way
Basic
Des Moines (DSM)to
Chicago (Midway) (MDW)Depart: 04/11/2026
From
$72
Seen: 2 hrs ago
One-way
Basic
Des Moines (DSM)to
Denver (DEN)Depart: 03/09/2026
From
$89
Seen: 2 hrs ago
One-way
Basic
Des Moines (DSM)to
Chicago (O'Hare) (ORD)Depart: 03/07/2026
From
$100
Seen: 11 hrs ago
One-way
Basic
Des Moines (DSM)to
Phoenix (PHX)Depart: 04/01/2026
From
$110
Seen: 13 hrs ago
One-way
Basic
Des Moines (DSM)to
Houston (Hobby) (HOU)Depart: 03/25/2026
From
$115
Seen: 1 hour ago
One-way
Basic
Des Moines (DSM)to
Tampa (TPA)Depart: 02/25/2026
From
$119
Seen: 12 hrs ago
One-way
Basic
Des Moines (DSM)to
Miami (MIA)Depart: 04/15/2026
From
$129
Seen: 8 hrs ago
One-way
Basic
Des Moines (DSM)to
Fort Lauderdale (FLL)Depart: 03/04/2026
From
$131
Seen: 22 hrs ago
One-way
Basic
Des Moines (DSM)to
Fort Myers/Naples (RSW)Depart: 03/03/2026
From
$131
Seen: 54 minutes ago
One-way
Basic
Des Moines (DSM)to
Long Beach (LGB)Depart: 03/17/2026
From
$133
Seen: 12 hrs ago
One-way
Basic
Des Moines (DSM)to
Raleigh/Durham (RDU)Depart: 02/24/2026
From
$136
Seen: 23 hrs ago
One-way
Basic
*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.
Traveling from Des Moines
Southwest Airlines is proud to serve Des Moines International Airport.
Home might be where the heartland is, but Southwest flights out of Des Moines International Airport make it simple to find a change of scenery. No matter how you get to the airport, we make it easy for Iowans to find a great deal on flights and get where they’re going from Des Moines.
Whether you’ve got your sights set on a scenic mountainside getaway or an action-packed adventure in a new city, or you’re ready to warm up or hit the slopes in wintertime, your destination is only a flight away from Des Moines. Swap the Des Moines River for a clear mountain stream beneath the stars or enjoy the bright lights of another bustling big city. Explore the destination options available through Southwest and see which potential getaway really grabs you.
Details about Des Moines Airport
Airport code:
DSM
City:
Des Moines
State:
Iowa
Concourse:
Concourse C
Gates:
Gate C1
Airport-provided WiFi
Cities with weekly flights from DSM:
117†
Cities with daily nonstop flights Monday through Friday from DSM:
4‡
Cities with daily nonstop flights Saturday through Sunday from DSM:
8§
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 10/1/2025 and 10/31/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 10/1/2025 and 10/31/2025.
Popular Destinations from Des Moines
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From | To | Fare Type | Dates | Price | |
|---|---|---|---|---|---|
| Des Moines (DSM) | St. Louis (STL) | One-way / Basic | Depart: 02/24/2026 | From $49 Seen: 19 hrs ago | |
| Des Moines (DSM) | Chicago (Midway) (MDW) | One-way / Basic | Depart: 04/11/2026 | From $72 Seen: 2 hrs ago | |
| Des Moines (DSM) | Denver (DEN) | One-way / Basic | Depart: 03/09/2026 | From $89 Seen: 2 hrs ago | |
| Des Moines (DSM) | Chicago (O'Hare) (ORD) | One-way / Basic | Depart: 03/07/2026 | From $100 Seen: 11 hrs ago | |
| Des Moines (DSM) | Phoenix (PHX) | One-way / Basic | Depart: 04/01/2026 | From $110 Seen: 13 hrs ago | |
| Des Moines (DSM) | Houston (Hobby) (HOU) | One-way / Basic | Depart: 05/05/2026 | From $115 Seen: 8 hrs ago | |
| Des Moines (DSM) | Tampa (TPA) | One-way / Basic | Depart: 03/04/2026 | From $119 Seen: 12 hrs ago | |
| Des Moines (DSM) | Miami (MIA) | One-way / Basic | Depart: 04/15/2026 | From $129 Seen: 8 hrs ago |
*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.
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