Southwest® flights from Greenville-Spartanburg starting at $78
Book flights from Greenville-Spartanburg with Southwest Airlines

Greenville-Spartanburg (GSP)to
Washington, D.C. (Reagan National) (DCA)
Greenville-Spartanburg (GSP)to
Fort Lauderdale (FLL)
Greenville-Spartanburg (GSP)to
New Orleans (MSY)
Greenville-Spartanburg (GSP)to
West Palm Beach (PBI)
Greenville-Spartanburg (GSP)to
Austin (AUS)
Greenville-Spartanburg (GSP)to
Fort Myers/Naples (RSW)
Greenville-Spartanburg (GSP)to
Tampa (TPA)
Greenville-Spartanburg (GSP)to
San Antonio (SAT)
Greenville-Spartanburg (GSP)to
Milwaukee (MKE)
Greenville-Spartanburg (GSP)to
Miami (MIA)
Greenville-Spartanburg (GSP)to
Phoenix (PHX)
Greenville-Spartanburg (GSP)to
Boston (BOS)*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.
Traveling from Greenville-Spartanburg
Southwest Airlines proudly serves Greenville-Spartanburg International Airport.
Say goodbye to Greenville-Spartanburg and board a Southwest® flight to your next adventure. South Carolina Upcountry has plenty to do and see, but it doesn’t have everything. Trade the Blue Ridge Mountains for the Rockies and enjoy life on another kind of mountain time. Or head to the Midwest for flat terrain interrupted by skylines that reach into the clouds—and you can reach a whole new kind of thrilling summit. Or head out West for deserts, Hollywood, and the Pacific Ocean. Wherever you choose to travel next, Southwest can get you there.
See more than the Upcountry of South Carolina when you fly with Southwest Airlines. Whether you choose to lounge on an oceanside beach towel, summit a mountain beyond the Appalachians, or experience the big-city way of life, you can board a flight at Greenville-Spartanburg International Airport and be on your way. Start exploring where you can fly when departing from Greenville-Spartanburg and make your move. Create your dream vacation with Southwest and rack up Rapid Rewards® points when you fly. Booking will be straightforward from flight selection to checkout to boarding; it’s all part of the Southwest Experience.
Details about Greenville-Spartanburg International Airport

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 10/1/2025 and 10/31/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 10/1/2025 and 10/31/2025.
Popular Destinations from Greenville-Spartanburg
From | To | Fare Type | Dates | Price | |
|---|---|---|---|---|---|
| Greenville-Spartanburg (GSP) | Baltimore/Washington (BWI) | One-way / Basic | Depart: 02/09/2026 | From $115 Seen: 19 hrs ago | |
| Greenville-Spartanburg (GSP) | Nashville (BNA) | One-way / Basic | Depart: 02/07/2026 | From $127 Seen: 9 hrs ago | |
| Greenville-Spartanburg (GSP) | Orlando (MCO) | One-way / Basic | Depart: 12/17/2025 | From $129 Seen: 5 hrs ago | |
| Greenville-Spartanburg (GSP) | Denver (DEN) | One-way / Basic | Depart: 02/14/2026 | From $124 Seen: 7 hrs ago | |
| Greenville-Spartanburg (GSP) | Las Vegas (LAS) | One-way / Basic | Depart: 01/31/2026 | From $169 Seen: 12 hrs ago | |
| Greenville-Spartanburg (GSP) | Dallas (Love Field) (DAL) | One-way / Basic | Depart: 01/06/2026 | From $133 Seen: 8 hrs ago | |
| Greenville-Spartanburg (GSP) | Houston (Hobby) (HOU) | One-way / Basic | Depart: 01/21/2026 | From $110 Seen: 8 hrs ago | |
| Greenville-Spartanburg (GSP) | Tampa (TPA) | One-way / Basic | Depart: 02/04/2026 | From $101 Seen: 2 hrs ago |
*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.
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