Southwest® flights from Buffalo/Niagara Falls to San Francisco from $112

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Low fares from Buffalo/Niagara Falls to San Francisco

$

Buffalo/Niagara Falls (BUF)to

San Francisco (SFO)
Depart: 11/25/2026

One-way

Basic

From
$112
Seen: 20 hrs ago

Buffalo/Niagara Falls (BUF)to

San Francisco (SFO)
Depart: 12/03/2026

One-way

Basic

From
$112
Seen: 9 hrs ago

Buffalo/Niagara Falls (BUF)to

San Francisco (SFO)
Depart: 11/16/2026

One-way

Basic

From
$112
Seen: 10 hrs ago

Buffalo/Niagara Falls (BUF)to

San Francisco (SFO)
Depart: 11/10/2026

One-way

Basic

From
$112
Seen: 10 hrs ago

Buffalo/Niagara Falls (BUF)to

San Francisco (SFO)
Depart: 11/17/2026

One-way

Basic

From
$112
Seen: 10 hrs ago

Buffalo/Niagara Falls (BUF)to

San Francisco (SFO)
Depart: 12/07/2026

One-way

Basic

From
$112
Seen: 8 hrs ago

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Explore flights from Buffalo/Niagara Falls to San Francisco

Oct 2026
From$295*
Seen: 15 hrs ago
One Way/Basic
Nov 2026
From$112*
Seen: 10 hrs ago
One Way/Basic
Dec 2026
From$112*
Seen: 8 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $112
Displaying fares for October-2026
  • BUF–SFO, 10/22/2026: From $360
    22

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    OCT

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    26

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    27

    Tue

  • BUF–SFO, 10/28/2026: From $295
    28

    Wed

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    29

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    30

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    31

    Sat

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    NOV

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    02

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    03

    Tue

  • BUF–SFO, 11/04/2026: From $239
    04

    Wed

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    05

    Thu

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    06

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    07

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    08

    Sun

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    09

    Mon

  • BUF–SFO, 11/10/2026: From $112
    10

    Tue

  • BUF–SFO: cmp-view-offers-disclaimer. Find Offers
    11

    Wed

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    12

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    13

    Fri

  • BUF–SFO: cmp-view-offers-disclaimer. Find Offers
    14

    Sat

  • BUF–SFO, 11/15/2026: From $143
    15

    Sun

  • BUF–SFO, 11/16/2026: From $112
    16

    Mon

  • BUF–SFO, 11/17/2026: From $112
    17

    Tue

  • BUF–SFO: cmp-view-offers-disclaimer. Find Offers
    18

    Wed

  • BUF–SFO: cmp-view-offers-disclaimer. Find Offers
    19

    Thu

  • BUF–SFO, 11/20/2026: From $226
    20

    Fri

  • BUF–SFO, 11/21/2026: From $117
    21

    Sat

    • Range$112-$360

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Buffalo Niagara International Airport
    Arriving at:
    San Francisco International Airport
    Distance:
    2309 miles

    Questions we hear the most

    There are 83 weekly flights from Buffalo/Niagara Falls to San Francisco on Southwest Airlines.
    To find the lowest fares by day and time to fly Buffalo/Niagara Falls to San Francisco with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Francisco International Airport book yours with your flight.
    Yes! Flights from Buffalo/Niagara Falls to San Francisco—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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