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Find low faresSouthwest® flights from Buffalo/Niagara Falls to Myrtle Beach from $149
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1 Passenger
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Low fares from Buffalo/Niagara Falls to Myrtle Beach
$
Buffalo/Niagara Falls (BUF)to
Myrtle Beach (MYR)
Depart: 03/10/2026
One-way
Basic
From
$149
Seen: 8 hrs ago
Buffalo/Niagara Falls (BUF)to
Myrtle Beach (MYR)
Depart: 03/17/2026
One-way
Basic
From
$149
Seen: 7 hrs ago
Buffalo/Niagara Falls (BUF)to
Myrtle Beach (MYR)
Depart: 03/04/2026
One-way
Basic
From
$149
Seen: 5 hrs ago
Buffalo/Niagara Falls (BUF)to
Myrtle Beach (MYR)
Depart: 02/25/2026
One-way
Basic
From
$149
Seen: 4 hrs ago
Buffalo/Niagara Falls (BUF)to
Myrtle Beach (MYR)
Depart: 02/21/2026
One-way
Basic
From
$149
Seen: 3 hrs ago
Buffalo/Niagara Falls (BUF)to
Myrtle Beach (MYR)
Depart: 03/18/2026
One-way
Basic
From
$149
Seen: 14 hrs ago
Explore flights from Buffalo/Niagara Falls to Myrtle Beach
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Flight Details
Departing from:
Buffalo Niagara International Airport
Arriving at:
Myrtle Beach International Airport
Distance:
639 miles
Route Information
69† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 69 weekly flights from Buffalo/Niagara Falls to Myrtle Beach on Southwest Airlines.
To find the lowest fares by day and time to fly Buffalo/Niagara Falls to Myrtle Beach with Southwest, check out our Low Fare Calendar.
You can rent a car at Myrtle Beach International Airport book yours with your flight.
Yes! Flights from Buffalo/Niagara Falls to Myrtle Beach—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.