Southwest® flights from Denver to Des Moines from $135

Promo Code

Low fares from Denver to Des Moines

$

Denver (DEN)to

Des Moines (DSM)
Depart: 11/26/2026

One-way

Basic

From
$135
Seen: 11 hrs ago

Denver (DEN)to

Des Moines (DSM)
Depart: 11/23/2026

One-way

Basic

From
$135
Seen: 14 hrs ago

Denver (DEN)to

Des Moines (DSM)
Depart: 10/14/2026

One-way

Basic

From
$135
Seen: 6 hrs ago

Denver (DEN)to

Des Moines (DSM)
Depart: 12/17/2026

One-way

Basic

From
$135
Seen: 5 hrs ago

Denver (DEN)to

Des Moines (DSM)
Depart: 10/22/2026

One-way

Basic

From
$135
Seen: 16 hrs ago

Denver (DEN)to

Des Moines (DSM)
Depart: 10/29/2026

One-way

Basic

From
$135
Seen: 12 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Denver to Des Moines

Sep 2026
From$135*
Seen: 14 hrs ago
One Way/Basic
Oct 2026
From$135*
Seen: 16 hrs ago
One Way/Basic
Nov 2026
From$135*
Seen: 13 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $135
cmp-daily-histogram-bars-legend-max-price-aria-label $482
Displaying fares for September-2026
  • DEN–DSM, 09/11/2026: From $482
    11

    Fri

    SEP

  • DEN–DSM, 09/12/2026: From $482
    12

    Sat

  • DEN–DSM, 09/13/2026: From $482
    13

    Sun

  • DEN–DSM: cmp-view-offers-disclaimer. Find Offers
    14

    Mon

  • DEN–DSM, 09/15/2026: From $482
    15

    Tue

  • DEN–DSM, 09/16/2026: From $309
    16

    Wed

  • DEN–DSM, 09/17/2026: From $309
    17

    Thu

  • DEN–DSM, 09/18/2026: From $309
    18

    Fri

  • DEN–DSM, 09/19/2026: From $309
    19

    Sat

  • DEN–DSM, 09/20/2026: From $309
    20

    Sun

  • DEN–DSM, 09/21/2026: From $309
    21

    Mon

  • DEN–DSM, 09/22/2026: From $309
    22

    Tue

  • DEN–DSM: cmp-view-offers-disclaimer. Find Offers
    23

    Wed

  • DEN–DSM, 09/24/2026: From $215
    24

    Thu

  • DEN–DSM: cmp-view-offers-disclaimer. Find Offers
    25

    Fri

  • DEN–DSM: cmp-view-offers-disclaimer. Find Offers
    26

    Sat

  • DEN–DSM: cmp-view-offers-disclaimer. Find Offers
    27

    Sun

  • DEN–DSM, 09/28/2026: From $235
    28

    Mon

  • DEN–DSM, 09/29/2026: From $215
    29

    Tue

  • DEN–DSM, 09/30/2026: From $135
    30

    Wed

  • DEN–DSM, 10/01/2026: From $185
    01

    Thu

    OCT

  • DEN–DSM, 10/02/2026: From $150
    02

    Fri

  • DEN–DSM: cmp-view-offers-disclaimer. Find Offers
    03

    Sat

  • DEN–DSM: cmp-view-offers-disclaimer. Find Offers
    04

    Sun

  • DEN–DSM: cmp-view-offers-disclaimer. Find Offers
    05

    Mon

  • DEN–DSM: cmp-view-offers-disclaimer. Find Offers
    06

    Tue

  • DEN–DSM: cmp-view-offers-disclaimer. Find Offers
    07

    Wed

  • DEN–DSM: cmp-view-offers-disclaimer. Find Offers
    08

    Thu

  • DEN–DSM, 10/09/2026: From $148
    09

    Fri

  • DEN–DSM: cmp-view-offers-disclaimer. Find Offers
    10

    Sat

    • Range$135-$482

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Denver International Airport
    Arriving at:
    Des Moines Airport
    Average flight time:
    1 hour 39 minutes
    Distance:
    589 miles

    Route Information

    75† Weekly flights
    • 1‡ Nonstop flight per day Monday through Friday
    • 1‡ Nonstop flight on Saturday
    • 1‡ Nonstop flight on Sunday

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    The average flight time from Denver to Des Moines is 1 hour 39 minutes.
    There are 75 weekly flights from Denver to Des Moines on Southwest Airlines.
    Yes, Southwest flies nonstop from Denver to Des Moines once per day from Monday through Friday.
    Yes, Southwest flies nonstop from Denver to Des Moines once per day on Saturdays and Sundays.
    To find the lowest fares by day and time to fly Denver to Des Moines with Southwest, check out our Low Fare Calendar.
    You can rent a car at Des Moines Airport book yours with your flight.
    Yes! Flights from Denver to Des Moines—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

    Explore Flights from Other Popular Origins

    Popular Flights from Denver