Southwest® flights from Fort Myers/Naples to Des Moines from $214

Promo Code

Low fares from Fort Myers/Naples to Des Moines

$

Fort Myers/Naples (RSW)to

Des Moines (DSM)
Depart: 02/26/2026

One-way

Basic

From
$214
Seen: 14 hrs ago

Fort Myers/Naples (RSW)to

Des Moines (DSM)
Depart: 02/20/2026

One-way

Basic

From
$244
Seen: 11 hrs ago

Fort Myers/Naples (RSW)to

Des Moines (DSM)
Depart: 02/26/2026

One-way

Choice

From
$254
Seen: 14 hrs ago

Fort Myers/Naples (RSW)to

Des Moines (DSM)
Depart: 04/20/2026

One-way

Basic

From
$270
Seen: 13 hrs ago

Fort Myers/Naples (RSW)to

Des Moines (DSM)
Depart: 02/20/2026

One-way

Choice

From
$284
Seen: 11 hrs ago

Fort Myers/Naples (RSW)to

Des Moines (DSM)
Depart: 04/20/2026

One-way

Choice

From
$310
Seen: 13 hrs ago

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Explore flights from Fort Myers/Naples to Des Moines

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Southwest Florida Regional Airport
Arriving at:
Des Moines Airport
Distance:
1236 miles

Route Information

42† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 42 weekly flights from Fort Myers/Naples to Des Moines on Southwest Airlines.
To find the lowest fares by day and time to fly Fort Myers/Naples to Des Moines with Southwest, check out our Low Fare Calendar.
You can rent a car at Des Moines Airport book yours with your flight.
Yes! Flights from Fort Myers/Naples to Des Moines—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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