Southwest® flights from Fort Myers/Naples to Des Moines from $207

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Low fares from Fort Myers/Naples to Des Moines

$

Fort Myers/Naples (RSW)to

Des Moines (DSM)
Depart: 10/05/2026

One-way

Basic

From
$207
Seen: 2 hrs ago

Fort Myers/Naples (RSW)to

Des Moines (DSM)
Depart: 10/24/2026

One-way

Basic

From
$217
Seen: 20 hrs ago

Fort Myers/Naples (RSW)to

Des Moines (DSM)
Depart: 10/05/2026

One-way

Choice

From
$252
Seen: 2 hrs ago

Fort Myers/Naples (RSW)to

Des Moines (DSM)
Depart: 10/24/2026

One-way

Choice

From
$262
Seen: 20 hrs ago

Fort Myers/Naples (RSW)to

Des Moines (DSM)
Depart: 10/12/2026

One-way

Basic

From
$269
Seen: 5 hrs ago

Fort Myers/Naples (RSW)to

Des Moines (DSM)
Depart: 09/28/2026

One-way

Basic

From
$306
Seen: 1 hour ago

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Explore flights from Fort Myers/Naples to Des Moines

Sep 2026
From$306*
Seen: 1 hour ago
One Way/Basic
Oct 2026
From$207*
Seen: 2 hrs ago
One Way/Basic
Nov 2026
No result for this month.
cmp-daily-histogram-bars-legend-min-price-aria-label $207
Displaying fares for September-2026
  • RSW–DSM: cmp-view-offers-disclaimer. Find Offers
    12

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    13

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    14

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    16

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  • RSW–DSM, 09/18/2026: From $454
    18

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    26

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    27

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  • RSW–DSM, 09/28/2026: From $306
    28

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    29

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    03

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  • RSW–DSM, 10/05/2026: From $207
    05

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    11

    Sun

    • Range$207-$454

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Southwest Florida Regional Airport
    Arriving at:
    Des Moines Airport
    Distance:
    1236 miles

    Route Information

    42† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 42 weekly flights from Fort Myers/Naples to Des Moines on Southwest Airlines.
    To find the lowest fares by day and time to fly Fort Myers/Naples to Des Moines with Southwest, check out our Low Fare Calendar.
    You can rent a car at Des Moines Airport book yours with your flight.
    Yes! Flights from Fort Myers/Naples to Des Moines—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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