Southwest® flights from Long Island/Islip MacArthur to Knoxville from $138

Promo Code

Low fares from Long Island/Islip MacArthur to Knoxville

$

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 01/11/2027

One-way

Basic

From
$138

Low fares from Long Island/Islip MacArthur to Knoxville

$

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 01/11/2027

One-way

Basic

From
$138
Seen: 2 hrs ago

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 12/13/2026

One-way

Basic

From
$139
Seen: 22 hrs ago

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 01/11/2027

One-way

Choice

From
$181
Seen: 2 hrs ago

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 12/13/2026

One-way

Choice

From
$201
Seen: 22 hrs ago

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 11/24/2026

One-way

Basic

From
$235
Seen: 11 hrs ago

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 01/11/2027

One-way

Choice Preferred

From
$253
Seen: 2 hrs ago

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Explore flights from Long Island/Islip MacArthur to Knoxville

Oct 2026
From$359*
Seen: 16 hrs ago
One Way/Basic
Nov 2026
From$235*
Seen: 11 hrs ago
One Way/Basic
Dec 2026
From$139*
Seen: 22 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $359
Displaying fares for October-2026
  • ISP–TYS, 10/23/2026: From $404
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  • ISP–TYS, 10/29/2026: From $359
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  • ISP–TYS, 11/06/2026: From $464
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    • Range$359-$464

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Long Island MacArthur Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    684 miles

    Questions we hear the most

    There are 41 weekly flights from Long Island/Islip MacArthur to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Long Island/Islip MacArthur to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Long Island/Islip MacArthur to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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