Southwest® flights from Long Island/Islip MacArthur to Knoxville from $152

Promo Code

Low fares from Long Island/Islip MacArthur to Knoxville

$

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 10/24/2026

One-way

Basic

From
$152

Low fares from Long Island/Islip MacArthur to Knoxville

$

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 10/24/2026

One-way

Basic

From
$152
Seen: 9 hrs ago

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 08/25/2026

One-way

Basic

From
$152
Seen: 16 hrs ago

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 08/26/2026

One-way

Basic

From
$152
Seen: 23 hrs ago

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 10/23/2026

One-way

Basic

From
$168
Seen: 19 hrs ago

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 10/07/2026

One-way

Basic

From
$173
Seen: 3 hrs ago

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 10/26/2026

One-way

Basic

From
$184
Seen: 22 hrs ago

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Explore flights from Long Island/Islip MacArthur to Knoxville

Aug 2026
From$152*
Seen: 23 hrs ago
One Way/Basic
Sep 2026
From$199*
Seen: 21 hrs ago
One Way/Basic
Oct 2026
From$152*
Seen: 9 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $152
Displaying fares for August-2026
  • ISP–TYS: cmp-view-offers-disclaimer. Find Offers
    03

    Mon

    AUG

  • ISP–TYS, 08/04/2026: From $384
    04

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  • ISP–TYS, 08/05/2026: From $384
    05

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  • ISP–TYS, 08/06/2026: From $384
    06

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  • ISP–TYS, 08/10/2026: From $344
    10

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    11

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    12

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    13

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  • ISP–TYS, 08/14/2026: From $339
    14

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    19

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    20

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    21

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    22

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    23

    Sun

  • ISP–TYS, 08/24/2026: From $209
    24

    Mon

  • ISP–TYS, 08/25/2026: From $152
    25

    Tue

  • ISP–TYS, 08/26/2026: From $152
    26

    Wed

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    27

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    28

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    29

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    30

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    31

    Mon

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    01

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    SEP

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    • Range$152-$384

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Long Island MacArthur Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    684 miles

    Route Information

    41† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 41 weekly flights from Long Island/Islip MacArthur to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Long Island/Islip MacArthur to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Long Island/Islip MacArthur to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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