Southwest® flights from Long Island/Islip MacArthur to Knoxville from $150

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Flights available to book today. Service starts March 5, 2026.

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Low fares from Long Island/Islip MacArthur to Knoxville

$

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 04/25/2026

One-way

Basic

From
$150

Low fares from Long Island/Islip MacArthur to Knoxville

$

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 04/25/2026

One-way

Basic

From
$150
Seen: 3 hrs ago

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 04/30/2026

One-way

Basic

From
$155
Seen: 16 hrs ago

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 03/26/2026

One-way

Basic

From
$169
Seen: 10 hrs ago

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 03/06/2026

One-way

Basic

From
$169
Seen: 8 hrs ago

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 03/24/2026

One-way

Basic

From
$169
Seen: 15 hrs ago

Long Island/Islip MacArthur (ISP)to

Knoxville (TYS)
Depart: 03/25/2026

One-way

Basic

From
$169
Seen: 15 hrs ago

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Explore flights from Long Island/Islip MacArthur to Knoxville

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Long Island MacArthur Airport
Arriving at:
Mc Ghee Tyson Airport
Distance:
684 miles

Route Information

41† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 41 weekly flights from Long Island/Islip MacArthur to Knoxville on Southwest Airlines.
To find the lowest fares by day and time to fly Long Island/Islip MacArthur to Knoxville with Southwest, check out our Low Fare Calendar.
You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
Yes! Flights from Long Island/Islip MacArthur to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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