Southwest® flights from Louisville to San Diego from $161

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Low fares from Louisville to San Diego

$

Louisville (SDF)to

San Diego (SAN)
Depart: 10/20/2026

One-way

Basic

From
$161
Seen: 13 hrs ago

Louisville (SDF)to

San Diego (SAN)
Depart: 12/12/2026

One-way

Basic

From
$161
Seen: 8 hrs ago

Louisville (SDF)to

San Diego (SAN)
Depart: 10/19/2026

One-way

Basic

From
$161
Seen: 12 hrs ago

Louisville (SDF)to

San Diego (SAN)
Depart: 11/10/2026

One-way

Basic

From
$161
Seen: 2 hrs ago

Louisville (SDF)to

San Diego (SAN)
Depart: 11/12/2026

One-way

Basic

From
$161
Seen: 9 hrs ago

Louisville (SDF)to

San Diego (SAN)
Depart: 10/31/2026

One-way

Basic

From
$161
Seen: 12 hrs ago

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Explore flights from Louisville to San Diego

Sep 2026
From$294*
Seen: 6 hrs ago
One Way/Basic
Oct 2026
From$161*
Seen: 12 hrs ago
One Way/Basic
Nov 2026
From$161*
Seen: 9 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $173
cmp-daily-histogram-bars-legend-max-price-aria-label $564
Displaying fares for September-2026
  • SDF–SAN, 09/11/2026: From $564
    11

    Fri

    SEP

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    12

    Sat

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    13

    Sun

  • SDF–SAN, 09/14/2026: From $564
    14

    Mon

  • SDF–SAN, 09/15/2026: From $564
    15

    Tue

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    16

    Wed

  • SDF–SAN, 09/17/2026: From $499
    17

    Thu

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    18

    Fri

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    19

    Sat

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    20

    Sun

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    21

    Mon

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    22

    Tue

  • SDF–SAN, 09/23/2026: From $294
    23

    Wed

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    24

    Thu

  • SDF–SAN, 09/25/2026: From $294
    25

    Fri

  • SDF–SAN, 09/26/2026: From $294
    26

    Sat

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    27

    Sun

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    28

    Mon

  • SDF–SAN, 09/29/2026: From $294
    29

    Tue

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    30

    Wed

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    01

    Thu

    OCT

  • SDF–SAN, 10/02/2026: From $173
    02

    Fri

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    03

    Sat

  • SDF–SAN, 10/04/2026: From $314
    04

    Sun

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    05

    Mon

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    06

    Tue

  • SDF–SAN: cmp-view-offers-disclaimer. Find Offers
    07

    Wed

  • SDF–SAN, 10/08/2026: From $254
    08

    Thu

  • SDF–SAN, 10/09/2026: From $173
    09

    Fri

  • SDF–SAN, 10/10/2026: From $204
    10

    Sat

    • Range$173-$564

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Louisville International Airport
    Arriving at:
    San Diego International Airport
    Distance:
    1804 miles

    Route Information

    146† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 146 weekly flights from Louisville to San Diego on Southwest Airlines.
    To find the lowest fares by day and time to fly Louisville to San Diego with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Diego International Airport book yours with your flight.
    Yes! Flights from Louisville to San Diego—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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