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Find low faresSouthwest® flights from Louisville to San Francisco from $184
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1 Passenger
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Low fares from Louisville to San Francisco
$
Louisville (SDF)to
San Francisco (SFO)
Depart: 03/04/2026
One-way
Basic
From
$184
Seen: 9 hrs ago
Louisville (SDF)to
San Francisco (SFO)
Depart: 04/18/2026
One-way
Basic
From
$193
Seen: 14 hrs ago
Louisville (SDF)to
San Francisco (SFO)
Depart: 03/07/2026
One-way
Basic
From
$200
Seen: 6 hrs ago
Louisville (SDF)to
San Francisco (SFO)
Depart: 03/26/2026
One-way
Basic
From
$219
Seen: 15 hrs ago
Louisville (SDF)to
San Francisco (SFO)
Depart: 03/05/2026
One-way
Basic
From
$219
Seen: 9 hrs ago
Louisville (SDF)to
San Francisco (SFO)
Depart: 03/20/2026
One-way
Basic
From
$219
Seen: 13 hrs ago
Explore flights from Louisville to San Francisco
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Flight Details
Departing from:
Louisville International Airport
Arriving at:
San Francisco International Airport
Distance:
1990 miles
Route Information
80† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 80 weekly flights from Louisville to San Francisco on Southwest Airlines.
To find the lowest fares by day and time to fly Louisville to San Francisco with Southwest, check out our Low Fare Calendar.
You can rent a car at San Francisco International Airport book yours with your flight.
Yes! Flights from Louisville to San Francisco—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.