Southwest® flights from Louisville to San Francisco from $154

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Low fares from Louisville to San Francisco

$

Louisville (SDF)to

San Francisco (SFO)
Depart: 09/15/2026

One-way

Basic

From
$154
Seen: 23 hrs ago

Louisville (SDF)to

San Francisco (SFO)
Depart: 09/17/2026

One-way

Basic

From
$154
Seen: 5 hrs ago

Louisville (SDF)to

San Francisco (SFO)
Depart: 10/20/2026

One-way

Basic

From
$154
Seen: 9 hrs ago

Louisville (SDF)to

San Francisco (SFO)
Depart: 09/06/2026

One-way

Basic

From
$154
Seen: 1 hour ago

Louisville (SDF)to

San Francisco (SFO)
Depart: 09/18/2026

One-way

Basic

From
$154
Seen: 20 hrs ago

Louisville (SDF)to

San Francisco (SFO)
Depart: 10/26/2026

One-way

Basic

From
$154
Seen: 5 hrs ago

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Explore flights from Louisville to San Francisco

Aug 2026
From$154*
Seen: 1 hour ago
One Way/Basic
Sep 2026
From$154*
Seen: 20 hrs ago
One Way/Basic
Oct 2026
From$154*
Seen: 5 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $154
Displaying fares for August-2026
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    AUG

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  • SDF–SFO, 08/03/2026: From $376
    03

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  • SDF–SFO, 08/05/2026: From $291
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  • SDF–SFO, 08/08/2026: From $291
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  • SDF–SFO, 08/09/2026: From $400
    09

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    17

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    18

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  • SDF–SFO, 08/19/2026: From $154
    19

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  • SDF–SFO, 08/20/2026: From $154
    20

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    21

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    25

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    26

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    29

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    31

    Mon

    • Range$154-$400

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Louisville International Airport
    Arriving at:
    San Francisco International Airport
    Distance:
    1990 miles

    Route Information

    80† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 80 weekly flights from Louisville to San Francisco on Southwest Airlines.
    To find the lowest fares by day and time to fly Louisville to San Francisco with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Francisco International Airport book yours with your flight.
    Yes! Flights from Louisville to San Francisco—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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