Southwest® flights from Milwaukee to Des Moines from $149

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Low fares from Milwaukee to Des Moines

$

Milwaukee (MKE)to

Des Moines (DSM)
Depart: 11/09/2026

One-way

Basic

From
$149
Seen: 5 hrs ago

Milwaukee (MKE)to

Des Moines (DSM)
Depart: 11/08/2026

One-way

Basic

From
$159
Seen: 4 hrs ago

Milwaukee (MKE)to

Des Moines (DSM)
Depart: 11/25/2026

One-way

Basic

From
$174
Seen: 22 hrs ago

Milwaukee (MKE)to

Des Moines (DSM)
Depart: 11/09/2026

One-way

Choice

From
$184
Seen: 5 hrs ago

Milwaukee (MKE)to

Des Moines (DSM)
Depart: 11/08/2026

One-way

Choice

From
$194
Seen: 4 hrs ago

Milwaukee (MKE)to

Des Moines (DSM)
Depart: 11/25/2026

One-way

Choice

From
$209
Seen: 22 hrs ago

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Explore flights from Milwaukee to Des Moines

Sep 2026
From$309*
Seen: 6 hrs ago
One Way/Basic
Oct 2026
From$239*
Seen: 6 hrs ago
One Way/Basic
Nov 2026
From$149*
Seen: 5 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $239
Displaying fares for September-2026
  • MKE–DSM: cmp-view-offers-disclaimer. Find Offers
    24

    Thu

    SEP

  • MKE–DSM, 09/25/2026: From $475
    25

    Fri

  • MKE–DSM, 09/26/2026: From $315
    26

    Sat

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    27

    Sun

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    28

    Mon

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    29

    Tue

  • MKE–DSM, 09/30/2026: From $309
    30

    Wed

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    01

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    OCT

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    03

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    04

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    05

    Mon

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    06

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    07

    Wed

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    08

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    09

    Fri

  • MKE–DSM, 10/10/2026: From $239
    10

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    11

    Sun

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    12

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    13

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    14

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    15

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    16

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    17

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    18

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    19

    Mon

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    20

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    21

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    22

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    23

    Fri

    • Range$239-$475

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    General Mitchell Airport
    Arriving at:
    Des Moines Airport
    Distance:
    311 miles

    Route Information

    32† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 32 weekly flights from Milwaukee to Des Moines on Southwest Airlines.
    To find the lowest fares by day and time to fly Milwaukee to Des Moines with Southwest, check out our Low Fare Calendar.
    You can rent a car at Des Moines Airport book yours with your flight.
    Yes! Flights from Milwaukee to Des Moines—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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