Southwest® flights from New York (LaGuardia) to Knoxville from $160

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Low fares from New York (LaGuardia) to Knoxville

$

New York (LaGuardia) (LGA)to

Knoxville (TYS)
Depart: 11/13/2026

One-way

Basic

From
$160

Low fares from New York (LaGuardia) to Knoxville

$

New York (LaGuardia) (LGA)to

Knoxville (TYS)
Depart: 11/13/2026

One-way

Basic

From
$160
Seen: 6 hrs ago

New York (LaGuardia) (LGA)to

Knoxville (TYS)
Depart: 10/21/2026

One-way

Basic

From
$165
Seen: 8 hrs ago

New York (LaGuardia) (LGA)to

Knoxville (TYS)
Depart: 10/17/2026

One-way

Basic

From
$199
Seen: 3 hrs ago

New York (LaGuardia) (LGA)to

Knoxville (TYS)
Depart: 11/13/2026

One-way

Choice

From
$200
Seen: 6 hrs ago

New York (LaGuardia) (LGA)to

Knoxville (TYS)
Depart: 10/21/2026

One-way

Choice

From
$205
Seen: 8 hrs ago

New York (LaGuardia) (LGA)to

Knoxville (TYS)
Depart: 09/19/2026

One-way

Basic

From
$209
Seen: 20 hrs ago

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Explore flights from New York (LaGuardia) to Knoxville

Aug 2026
From$339*
Seen: 6 minutes ago
One Way/Basic
Sep 2026
From$209*
Seen: 20 hrs ago
One Way/Basic
Oct 2026
From$165*
Seen: 8 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $209
cmp-daily-histogram-bars-legend-max-price-aria-label $384
Displaying fares for August-2026
  • LGA–TYS, 08/24/2026: From $384
    24

    Mon

    AUG

  • LGA–TYS: cmp-view-offers-disclaimer. Find Offers
    25

    Tue

  • LGA–TYS, 08/26/2026: From $384
    26

    Wed

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    27

    Thu

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    28

    Fri

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    29

    Sat

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    30

    Sun

  • LGA–TYS, 08/31/2026: From $339
    31

    Mon

  • LGA–TYS: cmp-view-offers-disclaimer. Find Offers
    01

    Tue

    SEP

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    02

    Wed

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    03

    Thu

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    04

    Fri

  • LGA–TYS, 09/05/2026: From $339
    05

    Sat

  • LGA–TYS, 09/06/2026: From $224
    06

    Sun

  • LGA–TYS, 09/07/2026: From $274
    07

    Mon

  • LGA–TYS: cmp-view-offers-disclaimer. Find Offers
    08

    Tue

  • LGA–TYS: cmp-view-offers-disclaimer. Find Offers
    09

    Wed

  • LGA–TYS, 09/10/2026: From $224
    10

    Thu

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    11

    Fri

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    12

    Sat

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    13

    Sun

  • LGA–TYS: cmp-view-offers-disclaimer. Find Offers
    14

    Mon

  • LGA–TYS: cmp-view-offers-disclaimer. Find Offers
    15

    Tue

  • LGA–TYS: cmp-view-offers-disclaimer. Find Offers
    16

    Wed

  • LGA–TYS, 09/17/2026: From $339
    17

    Thu

  • LGA–TYS: cmp-view-offers-disclaimer. Find Offers
    18

    Fri

  • LGA–TYS, 09/19/2026: From $209
    19

    Sat

  • LGA–TYS, 09/20/2026: From $308
    20

    Sun

  • LGA–TYS, 09/21/2026: From $229
    21

    Mon

  • LGA–TYS: cmp-view-offers-disclaimer. Find Offers
    22

    Tue

  • LGA–TYS: cmp-view-offers-disclaimer. Find Offers
    23

    Wed

    • Range$209-$384

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    La Guardia Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    647 miles

    Route Information

    38† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 38 weekly flights from New York (LaGuardia) to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly New York (LaGuardia) to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from New York (LaGuardia) to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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