Southwest® flights from Orlando to St. Louis from $123
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Low fares from Orlando to St. Louis
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Orlando (MCO)to
St. Louis (STL)
Depart: 10/22/2026
One-way
Basic
From
$123
Seen: 1 hour ago
Orlando (MCO)to
St. Louis (STL)
Depart: 10/15/2026
One-way
Basic
From
$123
Seen: 5 hrs ago
Orlando (MCO)to
St. Louis (STL)
Depart: 11/19/2026
One-way
Basic
From
$123
Seen: 18 hrs ago
Orlando (MCO)to
St. Louis (STL)
Depart: 10/03/2026
One-way
Basic
From
$123
Seen: 5 hrs ago
Orlando (MCO)to
St. Louis (STL)
Depart: 11/10/2026
One-way
Basic
From
$123
Seen: 1 hour ago
Orlando (MCO)to
St. Louis (STL)
Depart: 11/17/2026
One-way
Basic
From
$123
Seen: 1 hour ago
Explore flights from Orlando to St. Louis
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Flight Details
Departing from:
Orlando International Airport
Arriving at:
Lambert-St Louis Int'l Airport
Average flight time:
2 hours 36 minutes
Distance:
882 miles
Route Information
156† Weekly flights
- 5‡ Nonstop flights per day Monday through Friday
- 5‡ Nonstop flights on Saturday
- 6‡ Nonstop flights on Sunday
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Explore St. Louis
St. Louis is known as the Gateway City, River City, and Rome of the West, among other things. This friendly Midwestern city on the Mississippi River is full of cultural history, interactive sights and sounds, and tasty regional food offerings including thin crust pizza with Provel cheese, gooey butter cake, and deep-fried toasted ravioli.
Start your visit with a ride up the Gateway Arch, the 630-foot tall stainless steel monument that affords amazing views of the city. Stop by the St. Louis Zoo, the St. Louis Science Center, and the City Museum for interactive experiences that kids and adults alike will love. Looking for something off the beaten path? Head to the Cathedral Basilica of St. Louis to see one of western hemisphere’s largest mosaic collections.
Questions we hear the most
The average flight time from Orlando to St. Louis is 2 hours 36 minutes.
There are 156 weekly flights from Orlando to St. Louis on Southwest Airlines.
Yes, Southwest flies nonstop from Orlando to St. Louis 5 times per day from Monday through Friday.
Yes, Southwest flies nonstop from Orlando to St. Louis 5 times per day on Saturdays and 6 times per day on Sundays.
To find the lowest fares by day and time to fly Orlando to St. Louis with Southwest, check out our Low Fare Calendar.
You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
Yes! Flights from Orlando to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.
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