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Find low faresSouthwest® flights from Panama City Beach, FL to Louisville from $157
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Low fares from Panama City Beach, FL to Louisville
$
Panama City Beach, FL (ECP)to
Louisville (SDF)
Depart: 03/18/2026
One-way
Basic
From
$157
Seen: 13 hrs ago
Panama City Beach, FL (ECP)to
Louisville (SDF)
Depart: 02/26/2026
One-way
Basic
From
$168
Seen: 17 hrs ago
Panama City Beach, FL (ECP)to
Louisville (SDF)
Depart: 03/18/2026
One-way
Choice
From
$192
Seen: 13 hrs ago
Panama City Beach, FL (ECP)to
Louisville (SDF)
Depart: 02/26/2026
One-way
Choice
From
$203
Seen: 17 hrs ago
Panama City Beach, FL (ECP)to
Louisville (SDF)
Depart: 02/22/2026
One-way
Basic
From
$226
Seen: 12 hrs ago
Panama City Beach, FL (ECP)to
Louisville (SDF)
Depart: 02/22/2026
One-way
Choice
From
$261
Seen: 12 hrs ago
Explore flights from Panama City Beach, FL to Louisville
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Flight Details
Departing from:
Northwest Florida Beaches International Airport
Arriving at:
Louisville International Airport
Distance:
539 miles
Route Information
41† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 41 weekly flights from Panama City Beach, FL to Louisville on Southwest Airlines.
To find the lowest fares by day and time to fly Panama City Beach, FL to Louisville with Southwest, check out our Low Fare Calendar.
You can rent a car at Louisville International Airport book yours with your flight.
Yes! Flights from Panama City Beach, FL to Louisville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.