Southwest® flights from Panama City Beach, FL to St. Louis from $135

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Low fares from Panama City Beach, FL to St. Louis

$

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 12/11/2026

One-way

Basic

From
$135
Seen: 12 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 11/21/2026

One-way

Basic

From
$135
Seen: 12 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 11/25/2026

One-way

Basic

From
$145
Seen: 17 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 01/21/2027

One-way

Basic

From
$145
Seen: 14 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 12/04/2026

One-way

Basic

From
$145
Seen: 2 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 11/13/2026

One-way

Basic

From
$145
Seen: 56 minutes ago

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Explore flights from Panama City Beach, FL to St. Louis

Oct 2026
From$340*
Seen: 20 hrs ago
One Way/Basic
Nov 2026
From$135*
Seen: 12 hrs ago
One Way/Basic
Dec 2026
From$135*
Seen: 12 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $145
cmp-daily-histogram-bars-legend-max-price-aria-label $480
Displaying fares for October-2026
  • ECP–STL, 10/21/2026: From $480
    21

    Wed

    OCT

  • ECP–STL, 10/22/2026: From $480
    22

    Thu

  • ECP–STL, 10/23/2026: From $480
    23

    Fri

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    24

    Sat

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    25

    Sun

  • ECP–STL, 10/26/2026: From $480
    26

    Mon

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    27

    Tue

  • ECP–STL, 10/28/2026: From $340
    28

    Wed

  • ECP–STL, 10/29/2026: From $340
    29

    Thu

  • ECP–STL, 10/30/2026: From $340
    30

    Fri

  • ECP–STL, 10/31/2026: From $340
    31

    Sat

  • ECP–STL, 11/01/2026: From $340
    01

    Sun

    NOV

  • ECP–STL, 11/02/2026: From $340
    02

    Mon

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    03

    Tue

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    04

    Wed

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    05

    Thu

  • ECP–STL, 11/06/2026: From $289
    06

    Fri

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    07

    Sat

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    08

    Sun

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    09

    Mon

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    10

    Tue

  • ECP–STL, 11/11/2026: From $172
    11

    Wed

  • ECP–STL, 11/12/2026: From $145
    12

    Thu

  • ECP–STL, 11/13/2026: From $145
    13

    Fri

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    14

    Sat

  • ECP–STL, 11/15/2026: From $400
    15

    Sun

  • ECP–STL, 11/16/2026: From $275
    16

    Mon

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    17

    Tue

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    18

    Wed

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    19

    Thu

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    20

    Fri

    • Range$145-$480

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Northwest Florida Beaches International Airport
    Arriving at:
    Lambert-St Louis Int'l Airport
    Average flight time:
    1 hour 48 minutes
    Distance:
    634 miles

    Questions we hear the most

    The average flight time from Panama City Beach, FL to St. Louis is 1 hour 48 minutes.
    There are 98 weekly flights from Panama City Beach, FL to St. Louis on Southwest Airlines.
    Yes, Southwest flies nonstop from Panama City Beach, FL to St. Louis once per day from Monday through Friday.
    Yes, Southwest flies nonstop from Panama City Beach, FL to St. Louis once per day on Saturdays and Sundays.
    To find the lowest fares by day and time to fly Panama City Beach, FL to St. Louis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
    Yes! Flights from Panama City Beach, FL to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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