Southwest® flights from Panama City Beach, FL to St. Louis from $109

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Low fares from Panama City Beach, FL to St. Louis

$

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 10/22/2026

One-way

Basic

From
$109
Seen: 8 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 10/27/2026

One-way

Basic

From
$109
Seen: 4 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 11/21/2026

One-way

Basic

From
$109
Seen: 7 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 11/18/2026

One-way

Basic

From
$114
Seen: 11 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 12/15/2026

One-way

Basic

From
$114
Seen: 4 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 12/17/2026

One-way

Basic

From
$114
Seen: 4 hrs ago

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Explore flights from Panama City Beach, FL to St. Louis

Oct 2026
From$109*
Seen: 4 hrs ago
One Way/Basic
Nov 2026
From$109*
Seen: 7 hrs ago
One Way/Basic
Dec 2026
From$114*
Seen: 4 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $109
cmp-daily-histogram-bars-legend-max-price-aria-label $470
Displaying fares for October-2026
  • ECP–STL, 10/01/2026: From $470
    01

    Thu

    OCT

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    02

    Fri

  • ECP–STL, 10/03/2026: From $470
    03

    Sat

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    04

    Sun

  • ECP–STL, 10/05/2026: From $470
    05

    Mon

  • ECP–STL, 10/06/2026: From $330
    06

    Tue

  • ECP–STL, 10/07/2026: From $330
    07

    Wed

  • ECP–STL, 10/08/2026: From $330
    08

    Thu

  • ECP–STL, 10/09/2026: From $330
    09

    Fri

  • ECP–STL, 10/10/2026: From $330
    10

    Sat

  • ECP–STL, 10/11/2026: From $330
    11

    Sun

  • ECP–STL, 10/12/2026: From $410
    12

    Mon

  • ECP–STL, 10/13/2026: From $279
    13

    Tue

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    14

    Wed

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    15

    Thu

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    16

    Fri

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    17

    Sat

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    18

    Sun

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    19

    Mon

  • ECP–STL, 10/20/2026: From $279
    20

    Tue

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    21

    Wed

  • ECP–STL, 10/22/2026: From $109
    22

    Thu

  • ECP–STL, 10/23/2026: From $170
    23

    Fri

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    24

    Sat

  • ECP–STL, 10/25/2026: From $405
    25

    Sun

  • ECP–STL, 10/26/2026: From $245
    26

    Mon

  • ECP–STL, 10/27/2026: From $109
    27

    Tue

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    28

    Wed

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    29

    Thu

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    30

    Fri

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    31

    Sat

    • Range$109-$470

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Northwest Florida Beaches International Airport
    Arriving at:
    Lambert-St Louis Int'l Airport
    Average flight time:
    1 hour 48 minutes
    Distance:
    634 miles

    Route Information

    98† Weekly flights
    • 1‡ Nonstop flight per day Monday through Friday
    • 1‡ Nonstop flight on Saturday
    • 1‡ Nonstop flight on Sunday

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    The average flight time from Panama City Beach, FL to St. Louis is 1 hour 48 minutes.
    There are 98 weekly flights from Panama City Beach, FL to St. Louis on Southwest Airlines.
    Yes, Southwest flies nonstop from Panama City Beach, FL to St. Louis once per day from Monday through Friday.
    Yes, Southwest flies nonstop from Panama City Beach, FL to St. Louis once per day on Saturdays and Sundays.
    To find the lowest fares by day and time to fly Panama City Beach, FL to St. Louis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
    Yes! Flights from Panama City Beach, FL to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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