Southwest® flights from Panama City Beach, FL to St. Louis from $130

Promo Code

Low fares from Panama City Beach, FL to St. Louis

$

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 01/05/2027

One-way

Basic

From
$130
Seen: 16 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 12/08/2026

One-way

Basic

From
$130
Seen: 19 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 12/22/2026

One-way

Basic

From
$135
Seen: 2 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 01/21/2027

One-way

Basic

From
$145
Seen: 2 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 12/07/2026

One-way

Basic

From
$145
Seen: 19 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 12/24/2026

One-way

Basic

From
$150
Seen: 5 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Panama City Beach, FL to St. Louis

Nov 2026
From$294*
Seen: 2 hrs ago
One Way/Basic
Dec 2026
From$130*
Seen: 19 hrs ago
One Way/Basic
Jan 2027
From$130*
Seen: 16 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $130
cmp-daily-histogram-bars-legend-max-price-aria-label $577
Displaying fares for November-2026
  • ECP–STL, 11/10/2026: From $485
    10

    Tue

    NOV

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    11

    Wed

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    12

    Thu

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    13

    Fri

  • ECP–STL, 11/14/2026: From $485
    14

    Sat

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    15

    Sun

  • ECP–STL, 11/16/2026: From $345
    16

    Mon

  • ECP–STL, 11/17/2026: From $345
    17

    Tue

  • ECP–STL, 11/18/2026: From $345
    18

    Wed

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    19

    Thu

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    20

    Fri

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    21

    Sat

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    22

    Sun

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    23

    Mon

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    24

    Tue

  • ECP–STL, 11/25/2026: From $294
    25

    Wed

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    26

    Thu

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    27

    Fri

  • ECP–STL, 11/28/2026: From $577
    28

    Sat

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    29

    Sun

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    30

    Mon

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    01

    Tue

    DEC

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    02

    Wed

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    03

    Thu

  • ECP–STL, 12/04/2026: From $155
    04

    Fri

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    05

    Sat

  • ECP–STL, 12/06/2026: From $275
    06

    Sun

  • ECP–STL, 12/07/2026: From $145
    07

    Mon

  • ECP–STL, 12/08/2026: From $130
    08

    Tue

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    09

    Wed

    • Range$130-$577

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Northwest Florida Beaches International Airport
    Arriving at:
    Lambert-St Louis Int'l Airport
    Average flight time:
    1 hour 48 minutes
    Distance:
    634 miles

    Questions we hear the most

    The average flight time from Panama City Beach, FL to St. Louis is 1 hour 48 minutes.
    There are 98 weekly flights from Panama City Beach, FL to St. Louis on Southwest Airlines.
    Yes, Southwest flies nonstop from Panama City Beach, FL to St. Louis once per day from Monday through Friday.
    Yes, Southwest flies nonstop from Panama City Beach, FL to St. Louis once per day on Saturdays and Sundays.
    To find the lowest fares by day and time to fly Panama City Beach, FL to St. Louis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
    Yes! Flights from Panama City Beach, FL to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

    Explore Flights from Other Popular Origins

    Popular Flights from Panama City Beach, FL