Southwest® flights from Panama City Beach, FL to St. Louis from $114

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Low fares from Panama City Beach, FL to St. Louis

$

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 09/23/2026

One-way

Basic

From
$114
Seen: 7 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 09/22/2026

One-way

Basic

From
$114
Seen: 13 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 10/08/2026

One-way

Basic

From
$114
Seen: 14 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 10/17/2026

One-way

Basic

From
$114
Seen: 3 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 10/06/2026

One-way

Basic

From
$114
Seen: 23 hrs ago

Panama City Beach, FL (ECP)to

St. Louis (STL)
Depart: 09/17/2026

One-way

Basic

From
$114
Seen: 10 hrs ago

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Explore flights from Panama City Beach, FL to St. Louis

Aug 2026
From$320*
Seen: 23 hrs ago
One Way/Basic
Sep 2026
From$114*
Seen: 13 hrs ago
One Way/Basic
Oct 2026
From$114*
Seen: 23 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $114
cmp-daily-histogram-bars-legend-max-price-aria-label $460
Displaying fares for August-2026
  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    21

    Fri

    AUG

  • ECP–STL, 08/22/2026: From $460
    22

    Sat

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    23

    Sun

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    24

    Mon

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    25

    Tue

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    26

    Wed

  • ECP–STL, 08/27/2026: From $320
    27

    Thu

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    28

    Fri

  • ECP–STL, 08/29/2026: From $320
    29

    Sat

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    30

    Sun

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    31

    Mon

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    01

    Tue

    SEP

  • ECP–STL, 09/02/2026: From $320
    02

    Wed

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    03

    Thu

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    04

    Fri

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    05

    Sat

  • ECP–STL, 09/06/2026: From $269
    06

    Sun

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    07

    Mon

  • ECP–STL, 09/08/2026: From $395
    08

    Tue

  • ECP–STL, 09/09/2026: From $269
    09

    Wed

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    10

    Thu

  • ECP–STL, 09/11/2026: From $145
    11

    Fri

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    12

    Sat

  • ECP–STL, 09/13/2026: From $249
    13

    Sun

  • ECP–STL, 09/14/2026: From $175
    14

    Mon

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    15

    Tue

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    16

    Wed

  • ECP–STL, 09/17/2026: From $114
    17

    Thu

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    18

    Fri

  • ECP–STL: cmp-view-offers-disclaimer. Find Offers
    19

    Sat

  • ECP–STL, 09/20/2026: From $239
    20

    Sun

    • Range$114-$460

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Northwest Florida Beaches International Airport
    Arriving at:
    Lambert-St Louis Int'l Airport
    Average flight time:
    1 hour 48 minutes
    Distance:
    634 miles

    Route Information

    98† Weekly flights
    • 1‡ Nonstop flight per day Monday through Friday
    • 1‡ Nonstop flight on Saturday
    • 1‡ Nonstop flight on Sunday

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    The average flight time from Panama City Beach, FL to St. Louis is 1 hour 48 minutes.
    There are 98 weekly flights from Panama City Beach, FL to St. Louis on Southwest Airlines.
    Yes, Southwest flies nonstop from Panama City Beach, FL to St. Louis once per day from Monday through Friday.
    Yes, Southwest flies nonstop from Panama City Beach, FL to St. Louis once per day on Saturdays and Sundays.
    To find the lowest fares by day and time to fly Panama City Beach, FL to St. Louis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
    Yes! Flights from Panama City Beach, FL to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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