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Find low faresSouthwest® flights from Panama City Beach, FL to San Diego from $181
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1 Passenger
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Low fares from Panama City Beach, FL to San Diego
$
Panama City Beach, FL (ECP)to
San Diego (SAN)
Depart: 04/02/2026
One-way
Basic
From
$181
Seen: 6 hrs ago
Panama City Beach, FL (ECP)to
San Diego (SAN)
Depart: 03/28/2026
One-way
Basic
From
$181
Seen: 6 hrs ago
Panama City Beach, FL (ECP)to
San Diego (SAN)
Depart: 04/08/2026
One-way
Basic
From
$181
Seen: 1 hour ago
Panama City Beach, FL (ECP)to
San Diego (SAN)
Depart: 03/27/2026
One-way
Basic
From
$219
Seen: 6 hrs ago
Panama City Beach, FL (ECP)to
San Diego (SAN)
Depart: 04/06/2026
One-way
Basic
From
$219
Seen: 1 hour ago
Panama City Beach, FL (ECP)to
San Diego (SAN)
Depart: 03/08/2026
One-way
Basic
From
$219
Seen: 23 hrs ago
Explore flights from Panama City Beach, FL to San Diego
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Flight Details
Departing from:
Northwest Florida Beaches International Airport
Arriving at:
San Diego International Airport
Distance:
1853 miles
Route Information
85† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 85 weekly flights from Panama City Beach, FL to San Diego on Southwest Airlines.
To find the lowest fares by day and time to fly Panama City Beach, FL to San Diego with Southwest, check out our Low Fare Calendar.
You can rent a car at San Diego International Airport book yours with your flight.
Yes! Flights from Panama City Beach, FL to San Diego—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.