Southwest® flights from San Antonio to Knoxville from $126

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Low fares from San Antonio to Knoxville

$

San Antonio (SAT)to

Knoxville (TYS)
Depart: 10/27/2026

One-way

Basic

From
$126

Low fares from San Antonio to Knoxville

$

San Antonio (SAT)to

Knoxville (TYS)
Depart: 10/27/2026

One-way

Basic

From
$126
Seen: 17 hrs ago

San Antonio (SAT)to

Knoxville (TYS)
Depart: 09/11/2026

One-way

Basic

From
$126
Seen: 16 hrs ago

San Antonio (SAT)to

Knoxville (TYS)
Depart: 11/11/2026

One-way

Basic

From
$126
Seen: 23 hrs ago

San Antonio (SAT)to

Knoxville (TYS)
Depart: 09/02/2026

One-way

Basic

From
$127
Seen: 8 hrs ago

San Antonio (SAT)to

Knoxville (TYS)
Depart: 10/17/2026

One-way

Basic

From
$131
Seen: 18 hrs ago

San Antonio (SAT)to

Knoxville (TYS)
Depart: 10/24/2026

One-way

Basic

From
$131
Seen: 23 hrs ago

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Explore flights from San Antonio to Knoxville

Aug 2026
From$295*
Seen: 19 hrs ago
One Way/Basic
Sep 2026
From$126*
Seen: 16 hrs ago
One Way/Basic
Oct 2026
From$126*
Seen: 17 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $126
cmp-daily-histogram-bars-legend-max-price-aria-label $341
Displaying fares for August-2026
  • SAT–TYS, 08/13/2026: From $341
    13

    Thu

    AUG

  • SAT–TYS, 08/14/2026: From $341
    14

    Fri

  • SAT–TYS: cmp-view-offers-disclaimer. Find Offers
    15

    Sat

  • SAT–TYS, 08/16/2026: From $341
    16

    Sun

  • SAT–TYS, 08/17/2026: From $341
    17

    Mon

  • SAT–TYS, 08/18/2026: From $295
    18

    Tue

  • SAT–TYS, 08/19/2026: From $295
    19

    Wed

  • SAT–TYS: cmp-view-offers-disclaimer. Find Offers
    20

    Thu

  • SAT–TYS, 08/21/2026: From $341
    21

    Fri

  • SAT–TYS: cmp-view-offers-disclaimer. Find Offers
    22

    Sat

  • SAT–TYS: cmp-view-offers-disclaimer. Find Offers
    23

    Sun

  • SAT–TYS: cmp-view-offers-disclaimer. Find Offers
    24

    Mon

  • SAT–TYS: cmp-view-offers-disclaimer. Find Offers
    25

    Tue

  • SAT–TYS: cmp-view-offers-disclaimer. Find Offers
    26

    Wed

  • SAT–TYS: cmp-view-offers-disclaimer. Find Offers
    27

    Thu

  • SAT–TYS: cmp-view-offers-disclaimer. Find Offers
    28

    Fri

  • SAT–TYS: cmp-view-offers-disclaimer. Find Offers
    29

    Sat

  • SAT–TYS: cmp-view-offers-disclaimer. Find Offers
    30

    Sun

  • SAT–TYS: cmp-view-offers-disclaimer. Find Offers
    31

    Mon

  • SAT–TYS, 09/01/2026: From $152
    01

    Tue

    SEP

  • SAT–TYS, 09/02/2026: From $127
    02

    Wed

  • SAT–TYS, 09/03/2026: From $219
    03

    Thu

  • SAT–TYS, 09/04/2026: From $257
    04

    Fri

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    05

    Sat

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    06

    Sun

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    07

    Mon

  • SAT–TYS: cmp-view-offers-disclaimer. Find Offers
    08

    Tue

  • SAT–TYS: cmp-view-offers-disclaimer. Find Offers
    09

    Wed

  • SAT–TYS, 09/10/2026: From $214
    10

    Thu

  • SAT–TYS, 09/11/2026: From $126
    11

    Fri

  • SAT–TYS: cmp-view-offers-disclaimer. Find Offers
    12

    Sat

    • Range$126-$341

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    San Antonio International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    947 miles

    Route Information

    56† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 56 weekly flights from San Antonio to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly San Antonio to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from San Antonio to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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