Southwest® flights from Santa Rosa to Knoxville from $341

Promo Code

Low fares from Santa Rosa to Knoxville

$

Santa Rosa (STS)to

Knoxville (TYS)
Depart: 05/01/2026

One-way

Basic

From
$341

Low fares from Santa Rosa to Knoxville

$

Santa Rosa (STS)to

Knoxville (TYS)
Depart: 05/01/2026

One-way

Basic

From
$341

Low fares from Santa Rosa to Knoxville

$

Santa Rosa (STS)to

Knoxville (TYS)
Depart: 05/01/2026

One-way

Basic

From
$341
Seen: 1 hour ago

Santa Rosa (STS)to

Knoxville (TYS)
Depart: 05/01/2026

One-way

Choice

From
$386
Seen: 1 hour ago

Santa Rosa (STS)to

Knoxville (TYS)
Depart: 05/01/2026

One-way

Choice Preferred

From
$466
Seen: 1 hour ago

Santa Rosa (STS)to

Knoxville (TYS)
Depart: 05/01/2026

One-way

Choice Extra

From
$526
Seen: 1 hour ago

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Explore flights from Santa Rosa to Knoxville

Try alternate month or interact with individual days below in order to find offers.
Apr 2026
No result for this month.
May 2026
From$341*
Seen: 1 hour ago
One Way/Basic
Jun 2026
No result for this month.
$341
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    • Range$341

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Charles M. Schulz–Sonoma County Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    2135 miles

    Route Information

    2† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 2 weekly flights from Santa Rosa to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Santa Rosa to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Santa Rosa to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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