Southwest® flights from Santa Rosa to Knoxville from $336

Promo Code

Low fares from Santa Rosa to Knoxville

$

Santa Rosa (STS)to

Knoxville (TYS)
Depart: 06/09/2026

One-way

Basic

From
$336

Low fares from Santa Rosa to Knoxville

$

Santa Rosa (STS)to

Knoxville (TYS)
Depart: 06/09/2026

One-way

Basic

From
$336

Low fares from Santa Rosa to Knoxville

$

Santa Rosa (STS)to

Knoxville (TYS)
Depart: 06/09/2026

One-way

Basic

From
$336
Seen: 17 hrs ago

Santa Rosa (STS)to

Knoxville (TYS)
Depart: 06/09/2026

One-way

Choice

From
$376
Seen: 17 hrs ago

Santa Rosa (STS)to

Knoxville (TYS)
Depart: 06/09/2026

One-way

Choice Preferred

From
$456
Seen: 17 hrs ago

Santa Rosa (STS)to

Knoxville (TYS)
Depart: 06/09/2026

One-way

Choice Extra

From
$516
Seen: 17 hrs ago

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    • *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Charles M. Schulz–Sonoma County Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    2135 miles

    Route Information

    2† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 2 weekly flights from Santa Rosa to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Santa Rosa to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Santa Rosa to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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