Southwest® flights from Charleston to Knoxville from $138

Promo Code
Knoxville

Visit Knoxville


Book your flight to Knoxville and explore mountain views, live music, and nearby adventures in Gatlinburg and Pigeon Forge.

Flights available to book today. Service starts March 5, 2026.

Find flights

Low fares from Charleston to Knoxville

$

Charleston (CHS)to

Knoxville (TYS)
Depart: 03/09/2026

One-way

Basic

From
$138

Low fares from Charleston to Knoxville

$

Charleston (CHS)to

Knoxville (TYS)
Depart: 03/09/2026

One-way

Basic

From
$138
Seen: 14 hrs ago

Charleston (CHS)to

Knoxville (TYS)
Depart: 04/29/2026

One-way

Basic

From
$141
Seen: 22 hrs ago

Charleston (CHS)to

Knoxville (TYS)
Depart: 03/09/2026

One-way

Choice

From
$162
Seen: 14 hrs ago

Charleston (CHS)to

Knoxville (TYS)
Depart: 03/05/2026

One-way

Basic

From
$169
Seen: 14 hrs ago

Charleston (CHS)to

Knoxville (TYS)
Depart: 04/29/2026

One-way

Choice

From
$171
Seen: 22 hrs ago

Charleston (CHS)to

Knoxville (TYS)
Depart: 03/05/2026

One-way

Choice

From
$199
Seen: 14 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Charleston to Knoxville

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Charleston International Airport
Arriving at:
Mc Ghee Tyson Airport
Distance:
302 miles

Route Information

41† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 41 weekly flights from Charleston to Knoxville on Southwest Airlines.
To find the lowest fares by day and time to fly Charleston to Knoxville with Southwest, check out our Low Fare Calendar.
You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
Yes! Flights from Charleston to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

Explore Flights from Other Popular Origins

Popular Flights from Charleston