Southwest® flights from Des Moines to Mexico
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Popular flight deals and low fares from Des Moines
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Des Moines (DSM)to
Cancun (CUN)Depart: 12/31/2025
From
$241
Seen: 43 minutes ago
One-way
Basic
Des Moines (DSM)to
Los Cabos (SJD)Depart: 12/05/2025
From
$442
Seen: 12 hrs ago
One-way
Choice
Des Moines (DSM)to
Puerto Vallarta (PVR)Depart: 12/17/2025
From
$326
Seen: 8 hrs ago
One-way
Basic
*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.
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From | To | Fare Type | Dates | Price |
|---|---|---|---|---|
| Des Moines (DSM) | Cancun (CUN) | One-way / Basic | Depart: 02/02/2026 | From $236 Seen: 6 hrs ago |
| Des Moines (DSM) | Los Cabos (SJD) | One-way / Basic | Depart: 02/06/2026 | From $307 Seen: 14 hrs ago |
| Des Moines (DSM) | Puerto Vallarta (PVR) | One-way / Basic | Depart: 02/09/2026 | From $291 Seen: 13 hrs ago |
*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.
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