Southwest® flights from Des Moines to Mexico
expand_more
1 Passenger
expand_morePromo Code
expand_moretoday
today
Popular flight deals and low fares from Des Moines
flight_takeoff
flight_land
$
Des Moines (DSM)to
Los Cabos (SJD)Depart: 09/22/2026
From
$353
Seen: 13 hrs ago
One-way
Basic
Des Moines (DSM)to
Cancun (CUN)Depart: 09/20/2026
From
$366
Seen: 14 hrs ago
One-way
Basic
Des Moines (DSM)to
Puerto Vallarta (PVR)Depart: 10/10/2026
From
$906
Seen: 11 hrs ago
One-way
Choice
*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.
Shop more flights from Des Moines
flight_takeoff
flight_land
$
From | To | Fare Type | Dates | Price |
|---|---|---|---|---|
| Des Moines (DSM) | Cancun (CUN) | One-way / Basic | Depart: 01/18/2027 | From $286 Seen: 1 hour ago |
| Des Moines (DSM) | Los Cabos (SJD) | One-way / Basic | Depart: 12/18/2026 | From $363 Seen: 15 hrs ago |
| Des Moines (DSM) | Puerto Vallarta (PVR) | One-way / Choice | Depart: 01/01/2027 | From $611 Seen: 20 hrs ago |
*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.
More Routes from Des Moines
Popular Routes from Southwest Airlines®
Explore Southwest Airlines® Top-Pick Destinations