Southwest® flights from Harlingen/South Padre Island to Knoxville from $201

Promo Code

Low fares from Harlingen/South Padre Island to Knoxville

$

Harlingen/South Padre Island (HRL)to

Knoxville (TYS)
Depart: 12/17/2026

One-way

Basic

From
$170

Low fares from Harlingen/South Padre Island to Knoxville

$

Harlingen/South Padre Island (HRL)to

Knoxville (TYS)
Depart: 11/25/2026

One-way

Basic

From
$201
Seen: 12 hrs ago

Harlingen/South Padre Island (HRL)to

Knoxville (TYS)
Depart: 09/01/2026

One-way

Basic

From
$222
Seen: 12 hrs ago

Harlingen/South Padre Island (HRL)to

Knoxville (TYS)
Depart: 11/25/2026

One-way

Choice

From
$246
Seen: 12 hrs ago

Harlingen/South Padre Island (HRL)to

Knoxville (TYS)
Depart: 09/03/2026

One-way

Basic

From
$250
Seen: 20 hrs ago

Harlingen/South Padre Island (HRL)to

Knoxville (TYS)
Depart: 09/04/2026

One-way

Basic

From
$256
Seen: 5 hrs ago

Harlingen/South Padre Island (HRL)to

Knoxville (TYS)
Depart: 09/01/2026

One-way

Choice

From
$267
Seen: 12 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Harlingen/South Padre Island to Knoxville

Sep 2026
From$222*
Seen: 12 hrs ago
One Way/Basic
Oct 2026
No result for this month.
Nov 2026
From$201*
Seen: 12 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $222
Displaying fares for September-2026
  • HRL–TYS, 09/01/2026: From $222
    01

    Tue

    SEP

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    02

    Wed

  • HRL–TYS, 09/03/2026: From $250
    03

    Thu

  • HRL–TYS, 09/04/2026: From $256
    04

    Fri

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    05

    Sat

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    06

    Sun

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    07

    Mon

  • HRL–TYS, 09/08/2026: From $311
    08

    Tue

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    09

    Wed

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    10

    Thu

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    11

    Fri

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    12

    Sat

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    13

    Sun

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    14

    Mon

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    15

    Tue

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    16

    Wed

  • HRL–TYS, 09/17/2026: From $280
    17

    Thu

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    18

    Fri

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    19

    Sat

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    20

    Sun

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    21

    Mon

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    22

    Tue

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    23

    Wed

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    24

    Thu

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    25

    Fri

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    26

    Sat

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    27

    Sun

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    28

    Mon

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    29

    Tue

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    30

    Wed

    • Range$222-$311

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Valley International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    1043 miles

    Route Information

    27† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 27 weekly flights from Harlingen/South Padre Island to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Harlingen/South Padre Island to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Harlingen/South Padre Island to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

    Explore Flights from Other Popular Origins

    Popular Flights from Harlingen/South Padre Island