Southwest® flights from Harlingen/South Padre Island to Knoxville from $166

Promo Code

Low fares from Harlingen/South Padre Island to Knoxville

$

Harlingen/South Padre Island (HRL)to

Knoxville (TYS)
Depart: 01/20/2027

One-way

Basic

From
$166

Low fares from Harlingen/South Padre Island to Knoxville

$

Harlingen/South Padre Island (HRL)to

Knoxville (TYS)
Depart: 01/20/2027

One-way

Basic

From
$166
Seen: 8 hrs ago

Harlingen/South Padre Island (HRL)to

Knoxville (TYS)
Depart: 11/18/2026

One-way

Basic

From
$166
Seen: 15 hrs ago

Harlingen/South Padre Island (HRL)to

Knoxville (TYS)
Depart: 11/12/2026

One-way

Basic

From
$180
Seen: 16 hrs ago

Harlingen/South Padre Island (HRL)to

Knoxville (TYS)
Depart: 11/11/2026

One-way

Basic

From
$180
Seen: 6 hrs ago

Harlingen/South Padre Island (HRL)to

Knoxville (TYS)
Depart: 12/20/2026

One-way

Basic

From
$205
Seen: 16 hrs ago

Harlingen/South Padre Island (HRL)to

Knoxville (TYS)
Depart: 11/23/2026

One-way

Basic

From
$205
Seen: 16 hrs ago

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Explore flights from Harlingen/South Padre Island to Knoxville

Oct 2026
From$205*
Seen: 8 hrs ago
One Way/Basic
Nov 2026
From$166*
Seen: 15 hrs ago
One Way/Basic
Dec 2026
From$205*
Seen: 16 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $180
Displaying fares for October-2026
  • HRL–TYS, 10/12/2026: From $315
    12

    Mon

    OCT

  • HRL–TYS: cmp-view-offers-disclaimer. Find Offers
    13

    Tue

  • HRL–TYS, 10/14/2026: From $481
    14

    Wed

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    15

    Thu

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    Fri

  • HRL–TYS, 10/17/2026: From $232
    17

    Sat

  • HRL–TYS, 10/18/2026: From $318
    18

    Sun

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    21

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    22

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    23

    Fri

  • HRL–TYS, 10/24/2026: From $232
    24

    Sat

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    25

    Sun

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    26

    Mon

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    27

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    28

    Wed

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    29

    Thu

  • HRL–TYS, 10/30/2026: From $205
    30

    Fri

  • HRL–TYS, 10/31/2026: From $205
    31

    Sat

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    NOV

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    05

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    06

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    10

    Tue

  • HRL–TYS, 11/11/2026: From $180
    11

    Wed

    • Range$180-$481

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Valley International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    1043 miles

    Questions we hear the most

    There are 27 weekly flights from Harlingen/South Padre Island to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Harlingen/South Padre Island to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Harlingen/South Padre Island to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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